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The Identity of Glutathione S -Transferase B with Ligandin, a Major Binding Protein of Liver
Open accessAbstract
Evidence is presented that ligandin, an intracellular protein involved in the binding of such anions as bilirubin, indocyanine green, and penicillin, is identical to glutathione S -transferase B (EC 2.5.1.18), an enzyme catalyzing the conjugation of glutathione with such electrophiles as 1-chloro-2,4-dinitrobenzene, 1,2-dichloro-4-nitrobenzene, iodomethane, ethacrynic acid, and bromosulfophthalein. The proteins, isolated by distinct methods, have the same specificity for substrates and for ligands, react in identical fashion to antibody produced against ligandin, bear entirely similar physical characteristics and amino acid composition, and are both induced in response to phenobarbital. Indocyanine green, one of the ligands that is not effective as a substrate, was shown to competitively inhibit the conjugation reaction. It is suggested that specificity is directed toward compounds with electrophilic sites.
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Cited by
Poland, A., Glover, E., & Kende, A. S. (1976) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)33205-2 · Cited by 1,370
(1979) · Advances in Cancer Research · doi:10.1016/s0065-230x(08)60848-9 · Cited by 1,163
Shih, P.-H., Yeh, C.-T., & Yen, G.-C. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf071933i · Cited by 334
Binding of nonsubstrate ligands to the glutathione S-transferases.
Ketley, J., Habig, W., & Jakoby, W. (1975) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)40723-0 · Cited by 277
Self-citationAshok, A., Rai, N. K., Tripathi, S., & Bandyopadhyay, S. (2015) · Toxicological Sciences · doi:10.1093/toxsci/kfu208 · Cited by 177
Metadata
- Authors
- Habig, W. H., Pabst, M. J., Fleischner, G., Gatmaitan, Z., Arias, I. M., & Jakoby, W. B.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1974-10
- Volume
- 71
- Issue
- 10
- Pages
- 3879-3882
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2026788277
- Cited by
- 539
- References
- 0
- FWCI
- 7.86
- Type
- journal article
- Language
- en
- Open access
- green
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- Habig, W. H., Pabst, M. J., Fleischner, G., Gatmaitan, Z., Arias, I. M., & Jakoby, W. B. (1974). The Identity of Glutathione S -Transferase B with Ligandin, a Major Binding Protein of Liver. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.71.10.3879
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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