The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Biosynthesis of Collagen Crosslinks: Increased Activity of Purified Lysyl Oxidase with Reconstituted Collagen Fibrils
Open accessAbstract
Lysyl oxidase catalyzes the formation of crosslinking aldehydes in collagen and elastin. This report demonstrates that the enzyme has high activity with collagen precipitated as native fibrils, an apparent K m of 0.95 μM, and low activity toward either soluble forms such as denatured collagen, isolated α chain, or isolated α1-CBl peptide, or precipitated collagen fibrils after pepsin treatment. These results indicate that the biosynthesis of the aldehyde crosslink intermediate probably occurs primarily after the onset of fibril formation in vivo . Biosynthesis of aldehydes and subsequent crosslinks may be related to the rate of fibril formation as well as to the concentration of lysyl oxidase in vivo .
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Cites
Cross-linking of collagen and elastin. Properties of lysyl oxidase
Siegel, R. C., Pinnell, S. R., & Martin, G. R. (1970) · Biochemistry · doi:10.1021/bi00825a004 · Cited by 345
Self-citationAction of Proteolytic Enzymes on Tropocollagen and Insoluble Collagen*
Drake, M. P., Davison, P. F., Bump, S., & Schmitt, F. O. (1966) · Biochemistry · doi:10.1021/bi00865a039 · Cited by 257
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Wolf, K., Alexander, S., Schacht, V., Coussens, L. M., von Andrian, U. H., van Rheenen, J., Deryugina, E., & Friedl, P. (2009) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2009.08.005 · Cited by 637
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Metadata
- Authors
- Siegel, R. C.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1974-12
- Volume
- 71
- Issue
- 12
- Pages
- 4826-4830
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2070866139
- Cited by
- 184
- References
- 2
- FWCI
- 6.62
- Type
- journal article
- Language
- en
- Open access
- green
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- Siegel, R. C. (1974). Biosynthesis of Collagen Crosslinks: Increased Activity of Purified Lysyl Oxidase with Reconstituted Collagen Fibrils. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.71.12.4826
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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