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Isolation of a Major Cell Surface Glycoprotein from Fibroblasts
Open accessAbstract
A cell surface component has been isolated in partially purified form from cultured chick embryo and chick heart fibroblasts. This glycoprotein is similar to a protein recently reported to be present at the surface of normal cells, and missing after neoplastic transformation. It is a major cell surface glycoprotein that is synthesized by cultured fibroblasts, but is not collagen. It is shown to be markedly trypsin-sensitive, and its recovery from the cell surface is dependent on cell density. It is excluded from Sephadex G-200, but is not rapidly sedimented by ultracentrifugation, and has an apparent molecular weight of 220,000. The isolation of this cell surface glycoprotein may now provide a means of determining its function.
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Citations
Cited by
Ignotz, R. A., & Massagué, J. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)35666-1 · Cited by 2,492
Ali, I. U., Mautner, V., Lanza, R., & Hynes, R. O. (1977) · Cell · doi:10.1016/0092-8674(77)90322-1 · Cited by 423
Plasma membrane glycoprotein which mediates adhesion of fibroblasts to collagen
PEARLSTEIN, E. (1976) · Nature · doi:10.1038/262497a0 · Cited by 386
Metadata
- Authors
- Yamada, K. M., & Weston, J. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1974-09
- Volume
- 71
- Issue
- 9
- Pages
- 3492-3496
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2145453639
- Cited by
- 294
- References
- 0
- FWCI
- 14.32
- Type
- journal article
- Language
- en
- Open access
- green
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- Yamada, K. M., & Weston, J. A. (1974). Isolation of a Major Cell Surface Glycoprotein from Fibroblasts. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.71.9.3492
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