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Detection of carcinogens as mutagens: bacterial tester strains with R factor plasmids.
Open accessAbstract
We described previously a simple test on petri plates for detecting chemical carcinogens as mutagens, using an especially sensitive set of bacterial strains to detect mutagenic acitivty and a mammalian liver extract for carcinogen activity. We now extend the utility of the method by introducing two new bacterial strains which can detect with great sensitivity many carcinogens which we did not detect before or detected with less sensitivity. Among these carcinogens are aflatoxin B-1, sterigmatocystin, benzyl chloride, benzo[a]-pyrene, 7,12-dimethylbenzanthracene, 1'-acetoxysafrole, and the nitrofuran food additive furylfuramide (AF-2). The new strains TA100 and TA98 contain an R factor plasmid, pKM101, in our standard tester strains TA1535 and TA1538. The R factor increases mutagenesis with certain mutagens, but not others. We present evidence that the mutagens that become more effective work through an error-prone recombinational repair.
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Citations
Cited by
Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli
Walker, G. C. (1984) · Microbiological Reviews · doi:10.1128/mmbr.48.1.60-93.1984 · Cited by 1,770
Naturally occurring carbonyl compounds are mutagens Salmonella tester strain TA104
J. Marnett, L., Hurd, H. K., Hollstein, M. C., Levin, D. E., Esterbauer, H., & Ames, B. N. (1985) · Mutation Research · doi:10.1016/0027-5107(85)90204-0 · Cited by 586
Self-citationGoodman, M. F., & Woodgate, R. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a010363 · Cited by 317
“The ability of MucA0B to increase mutagenesis in strains of Salmonella typhimurium exposed to a variety of DNA-damaging agents plays an important role in increasing the efficacy of the “Ames test” that was proposed as a possible way to identify human carcinogens (McCann et al. 1975).”
BackgroundA modified Luria-Delbrück fluctuation assay for estimating and comparing mutation rates
Crane, G. J., Thomas, S. M., & Jones, M. E. (1996) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/0027-5107(96)00009-7 · Cited by 42
Changes in the mutagenic and estrogenic activities of bisphenol A upon treatment with nitrite
Masuda, S., Terashima, Y., Sano, A., Kuruto, R., Sugiyama, Y., Shimoi, K., Tanji, K., Yoshioka, H., Terao, Y., & Kinae, N. (2005) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2005.04.005 · Cited by 35
Metadata
- Authors
- McCann, J., Spingarn, N. E., Kobori, J., & Ames, B. N.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1975-03
- Volume
- 72
- Issue
- 3
- Pages
- 979-983
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2068270570
- Cited by
- 1,016
- References
- 0
- FWCI
- 38.02
- Type
- journal article
- Language
- en
- Open access
- green
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- McCann, J., Spingarn, N. E., Kobori, J., & Ames, B. N. (1975). Detection of carcinogens as mutagens: bacterial tester strains with R factor plasmids. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.72.3.979
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