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Molecular basis of beta-galactosidase alpha-complementation.
Open accessAbstract
In previous studies, a cyanogen bromide peptide derived from amino-acid residues 3-92 of beta-galactosidase (EC 3.2.1.23; beta-D-galactoside galactohydrolase) was shown to have alpha-donor activity in intracistronic alpha-complementation. We have now isolated the defective beta-galactosidase alpha-acceptor protein from the deletion mutant strain M15 of Escherichia coli and find that it lacks residues 11-41 of betal-galactosidase. This is demonstrated by the isolation and sequence determination of a cyanogen bromide peptide from the M15 protein, which is identical to the corresponding peptide from beta-galactosidase except for the missing amino acids. We conclude that the alpha-donor peptide restores the region missing in the M15 protein.
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Cites
Principles that Govern the Folding of Protein Chains
Anfinsen, C. B. (1973) · Science · doi:10.1126/science.181.4096.223 · Cited by 7,096
Cited by
Casadaban, M. J., Chou, J., & Cohen, S. N. (1980) · Journal of Bacteriology · doi:10.1128/jb.143.2.971-980.1980 · Cited by 1,045
Three-dimensional structure of β-galactosidase from E. coli.
Jacobson, R. H., Zhang, X.-J., DuBose, R. F., & Matthews, B. W. (1994) · Nature · doi:10.1038/369761a0 · Cited by 600
A series of wide-host-range low-copy-number vectors that allow direct screening for recombinants
Morales, V. M., Bäckman, A., & Bagdasarian, M. (1991) · Gene · doi:10.1016/0378-1119(91)90007-x · Cited by 502
The gapped duplex DNA approach to oligonucleotide-directed mutation construction
Kramer, W., Drutsa, V., Jansen, H.-W., Kramer, B., Pflugfelder, M., & Fritz, H.-J. (1984) · Nucleic Acids Research · doi:10.1093/nar/12.24.9441 · Cited by 485
Coronavirus Cell Entry Occurs through the Endo-/Lysosomal Pathway in a Proteolysis-Dependent Manner
Burkard, C., Verheije, M. H., Wicht, O., van Kasteren, S. I., van Kuppeveld, F. J., Haagmans, B. L., Pelkmans, L., Rottier, P. J. M., Bosch, B. J., & de Haan, C. A. M. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004502 · Cited by 388
Metadata
- Authors
- Langley, K. E., Villarejo, M. R., Fowler, A. V., Zamenhof, P. J., & Zabin, I.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1975-04
- Volume
- 72
- Issue
- 4
- Pages
- 1254-1257
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1975646429
- Cited by
- 191
- References
- 1
- FWCI
- 4.15
- Type
- journal article
- Language
- en
- Open access
- green
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- Langley, K. E., Villarejo, M. R., Fowler, A. V., Zamenhof, P. J., & Zabin, I. (1975). Molecular basis of beta-galactosidase alpha-complementation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.72.4.1254
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