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Adenosine 3':5'-cyclic monophosphate as mediator of catabolite repression in Escherichia coli.
Open accessAbstract
Measurements of intracellular adenosine 3':5'-cyclic monophosphate (cAMP) concentrations in E. coli under a variety of conditions show that levels of this nucleotide are well correlated with the rate of synthesis of beta-galactosidase (beta-D-galactoside galactohydrolase, EC 3.2.1.23) in both catabolite repression and transient repression. These results, combined with extensive genetic and in vitro studies from a number of laboratories on the role of cAMP in E. coli, provide strong support for the concept that intracellular cAMP levels mediate the effects of catabolite and transient repression on rates on enzyme synthesis. Under all conditions studied, excretion can be described by a single rate constant, 2.1 min-1 at 37 degrees, indicating that intracellular levels cannot be regulated by alterations in the rate of cAMP excretion. Our data are fully consistent with the idea that carbon sources control intracellular cAMP levels by effects on its synthesis.
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Citations
Cited by
Recombinant protein expression in Escherichia coli: advances and challenges
Rosano, G. L., & Ceccarelli, E. A. (2014) · Frontiers in Microbiology · doi:10.3389/fmicb.2014.00172 · Cited by 2,556
Phosphoenolpyruvate:carbohydrate phosphotransferase systems of bacteria
Postma, P. W., Lengeler, J. W., & Jacobson, G. R. (1993) · Microbiological Reviews · doi:10.1128/mmbr.57.3.543-594.1993 · Cited by 1,903
Cyclic AMP Receptor Protein: Role in Transcription Activation
de Crombrugghe, B., Busby, S., & Buc, H. (1984) · Science · doi:10.1126/science.6372090 · Cited by 621
Coordination of bacterial proteome with metabolism by cyclic AMP signalling
You, C., Okano, H., Hui, S., Zhang, Z., Kim, M., Gunderson, C. W., Wang, Y.-P., Lenz, P., Yan, D., & Hwa, T. (2013) · Nature · doi:10.1038/nature12446 · Cited by 432
Cyclic adenosine 5'-monophosphate in Escherichia coli
Pastan, I., & Adhya, S. (1976) · Bacteriological Reviews · doi:10.1128/br.40.3.527-551.1976 · Cited by 397
Metadata
- Authors
- Epstein, W., Rothman-Denes, L. B., & Hesse, J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1975-06
- Volume
- 72
- Issue
- 6
- Pages
- 2300-2304
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2125556713
- Cited by
- 246
- References
- 0
- FWCI
- 8.90
- Type
- journal article
- Language
- en
- Open access
- green
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- Epstein, W., Rothman-Denes, L. B., & Hesse, J. (1975). Adenosine 3':5'-cyclic monophosphate as mediator of catabolite repression in Escherichia coli. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.72.6.2300
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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