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The ovary as a source of alpha-ecdysone in an adult mosquito.
Open accessAbstract
The ovaries of the mosquito Aedes aegypti cultured in vitro secrete material that behaves like ecdysone in a radioimmunoassay. The material was identified as alpha-ecdysone by high-resolution liquid and gas-liquid chromatography. Secretion reached a maximum 16 hr after a blood meal as shown by bioassay and direct determination. Ovariectomy reduced the concentration of ecdysone in the adult after a blood meal. Qualitative analysis of whole-body extracts indicated beta-ecdysone to be the principal species present. Thus the ovaries appear to secrete a prohormone, alpha-ecdysone, which is converted to beta-ecdysone. Beta-ecdysone plays a significant role in stimulating egg development in the adult mosquito and may have reproductive roles in other insects.
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Cited by
Ecdysone response genes govern egg chamber development during mid-oogenesis in Drosophila
Buszczak, M., Freeman, M. R., Carlson, J. R., Bender, M., Cooley, L., & Segraves, W. A. (1999) · Development · doi:10.1242/dev.126.20.4581 · Cited by 276
Separation of ecdysteroids by using high-pressure liquid chromatography on microparticulate supports
Lafont, R., Martin-Sommé, G., & Chambet, J.-C. (1979) · Journal of Chromatography A · doi:10.1016/s0021-9673(00)84250-8 · Cited by 32
Ecdysteroids as defensive chemicals
(2022) · Advances in Insect Physiology · doi:10.1016/bs.aiip.2022.09.001 · Cited by 11
Metadata
- Authors
- Hagedorn, H. H., O'Connor, J. D., Fuchs, M. S., Sage, B., Schlaeger, D. A., & Bohm, M. K.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1975-08
- Volume
- 72
- Issue
- 8
- Pages
- 3255-3259
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2095357678
- Cited by
- 412
- References
- 1
- FWCI
- 6.80
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Hagedorn, H. H., O'Connor, J. D., Fuchs, M. S., Sage, B., Schlaeger, D. A., & Bohm, M. K. (1975). The ovary as a source of alpha-ecdysone in an adult mosquito. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.72.8.3255
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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