The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Isolation, primary structure, and synthesis of α-endorphin and γ-endorphin, two peptides of hypothalamic-hypophysial origin with morphinomimetic activity
Open accessAbstract
The isolation and primary structure of two peptides with morphinomimetic activity, obtained from an extract of porcine hypothalamus-neurohypophysis, are described. The amino acid sequence of the two peptides, named α-endorphin and γ-endorphin, was determined by mass spectrometry and densyl-Edman methods to be H-Tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-OH and H-Tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-OH, respectively. These correspond to the amino acid sequences present between residues 61 and 76 and residues 61 and 77 of the various β-lipotropins. A third peptide also obtained in pure from in these studies was found to be an unstable salt of α-endorphin.
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Citations
Cites
Identification of two related pentapeptides from the brain with potent opiate agonist activity
Hughes, J., Smith, T. W., Kosterlitz, H. W., Fothergill, L. A., Morgan, B. A., & Morris, H. R. (1975) · Nature · doi:10.1038/258577a0 · Cited by 3,806
Cited by
Endogenous opioid peptides: multiple agonists and receptors
Lord, J. A. H., Waterfield, A. A., Hughes, J., & Kosterlitz, H. W. (1977) · Nature · doi:10.1038/267495a0 · Cited by 2,485
Nucleotide sequence of cloned cDNA for bovine corticotropin-β-lipotropin precursor
Nakanishi, S., Inoue, A., Kita, T., Inoue, A., Nakamura, M., Chang, A. C. Y., Cohen, S. N., & Numa, S. (1979) · Nature · doi:10.1038/278423a0 · Cited by 1,762
Opioid peptide enkephalin: immunohistochemical mapping in rat central nervous system.
Simantov, R., Kuhar, M. J., Uhl, G. R., & Snyder, S. H. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.5.2167 · Cited by 621
The opiomelanotropinergic neuronal and endocrine systems
O'Donohue, T. L., & Dorsa, D. M. (1982) · Peptides · doi:10.1016/0196-9781(82)90098-5 · Cited by 536
Peptides in the Brain: The New Endocrinology of the Neuron
Guillemin, R. (1978) · Science · doi:10.1126/science.212832 · Cited by 485
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Metadata
- Authors
- Ling, N., Burgus, R., & Guillemin, R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1976-11
- Volume
- 73
- Issue
- 11
- Pages
- 3942-3946
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2045757290
- Cited by
- 219
- References
- 1
- FWCI
- 9.75
- Type
- journal article
- Language
- en
- Open access
- green
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- Ling, N., Burgus, R., & Guillemin, R. (1976). Isolation, primary structure, and synthesis of α-endorphin and γ-endorphin, two peptides of hypothalamic-hypophysial origin with morphinomimetic activity. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.73.11.3942
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