The DOI matches its Crossref record.
Novobiocin and coumermycin inhibit DNA supercoiling catalyzed by DNA gyrase.
Open accessAbstract
Novobiocin and coumermycin are known to inhibit the replication of DNA iing of DNA catalyzed by E. coli DNA gyrase, a recently discovered enzyme that introduces negative superhelical turns into covalently circular DNA. The activity of DNA gyrase purified from a coumermycin-resistant mutant strain is resistant to both drugs. The inhibition by novobiocin of colicin E1 plasmid DNA replication in a cell-free system is partially relieved by adding resistant DNA gyrase. Both in the case of coliclls. DNA molecules which are converted to the covalently circular form in thepresence of coumermycin remain relaxed, instead of achieving their normal supercoiled conformation. We conclude that DNA gyrase controls the supercoiling of DNA in E. coli.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Linkage map of Escherichia coli K-12, edition 6
Bachmann, B., & Low, K. B. (1980) · Microbiological Reviews · doi:10.1128/mmbr.44.1.1-56.1980 · Cited by 938
Topoisomerases as anticancer targets
Delgado, J. L., Hsieh, C.-M., Chan, N.-L., & Hiasa, H. (2018) · Biochemical Journal · doi:10.1042/bcj20160583 · Cited by 481
DNA gyrase inhibitors: Progress and synthesis of potent compounds as antibacterial agents
Khan, T., Sankhe, K., Suvarna, V., Sherje, A., Patel, K., & Dravyakar, B. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.04.021 · Cited by 253
Defined chromosome structure in the genome-reduced bacterium Mycoplasma pneumoniae
Trussart, M., Yus, E., Martinez, S., Baù, D., Tahara, Y. O., Pengo, T., Widjaja, M., Kretschmer, S., Swoger, J., Djordjevic, S., et al. (2017) · Nature Communications · doi:10.1038/ncomms14665 · Cited by 114
Metadata
- Authors
- Gellert, M., O'Dea, M. H., Itoh, T., & Tomizawa, J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1976-12
- Volume
- 73
- Issue
- 12
- Pages
- 4474-4478
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2059096132
- Cited by
- 727
- References
- 0
- FWCI
- 22.44
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Novobiocin and coumermycin inhibit DNA supercoiling catalyzed by DNA gyrase. https://app.cochat.ai/papers/10.1073/pnas.73.12.4474
- The paper
- Gellert, M., O'Dea, M. H., Itoh, T., & Tomizawa, J. (1976). Novobiocin and coumermycin inhibit DNA supercoiling catalyzed by DNA gyrase. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.73.12.4474
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
