The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Biological consequences of incorporation of 5-fluorocytidine in the RNA of 5-fluorouracil-treated eukaryotic cells
Open accessAbstract
Treatment of HeLa cells with 5-fluoro-[3H]uracil leads to the incorporation into cellular RNA of 5-fluorocytidine to the extent of about 0.2% of the 5-fluorouridine incorporated. In tobacco mosaic virus RNA produced in tobacco leaves this ratio is one order of magnitude lower. Copolymers of cytidylic with 5-fluorocytidylic acids show unchanged template activity with E. coli RNA polymerase, but slightly altered messenger activity in the wheat germ system, compared to poly(C), and it is suggested that some of the biological consequences of 5-fluorouracil treatment of living cells and organisms may be attributed to this mechanism.
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Aviv, H., & Leder, P. (1972) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.69.6.1408 · Cited by 6,636
PLAQUE FORMATION AND ISOLATION OF PURE LINES WITH POLIOMYELITIS VIRUSES
Dulbecco, R., & Vogt, M. (1954) · The Journal of Experimental Medicine · doi:10.1084/jem.99.2.167 · Cited by 3,819
Plaque production by the polyoma virus
Dulbecco, R., & Freeman, G. (1959) · Virology · doi:10.1016/0042-6822(59)90043-1 · Cited by 671
Marcu, K. B., & DUDOCK, B. S. (1974) · Nucleic Acids Research · doi:10.1093/nar/1.11.1385 · Cited by 337
Litman, R. M., & Pardee, A. B. (1956) · Nature · doi:10.1038/178529b0 · Cited by 160
Dunn, D. B., & Smith, J. (1957) · Biochemical Journal · doi:10.1042/bj0670494 · Cited by 136
Studies on the incorporation of 5-fluorouracil into a virus nucleic acid
Gordon, M. P., & STAEHELIN, M. (1959) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(59)90177-5 · Cited by 75
Relationship between the mutagenic and base-stacking properties of halogenated uracil derivatives
Sternglanz, H., & Bugg, C. E. (1975) · Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis · doi:10.1016/0005-2787(75)90130-6 · Cited by 71
Messenger and template activities of chemically modified polynucleotides
Singer, B., & Fraenkel‐Conrat, H. (1970) · Biochemistry · doi:10.1021/bi00821a007 · Cited by 64
Self-citationPolynucleotide analogues II. Stimulation of amino acid incorporation by polynucleotide analogues
GRUNBERG‐MANAGO, M., & Michelson, A. M. (1964) · Biochimica et Biophysica Acta (BBA) - Specialized Section on Nucleic Acids and Related Subjects · doi:10.1016/0926-6550(64)90145-8 · Cited by 60
Miscoding caused by 5-fluorouracil
Rosen, B. P., Rothman, F. G., & WEIGERT, M. G. (1969) · Journal of Molecular Biology · doi:10.1016/0022-2836(69)90181-8 · Cited by 58
The incorporation of 5-fluorouracil into poliovirus
Munyon, W. H., & Salzman, N. P. (1962) · Virology · doi:10.1016/0042-6822(62)90181-2 · Cited by 57
Kramer, G., Wittmann, H. G., & Schuster, H. (1964) · Zeitschrift für Naturforschung B · doi:10.1515/znb-1964-0111 · Cited by 39
Holoubek, V. (1963) · Journal of Molecular Biology · doi:10.1016/s0022-2836(63)80133-3 · Cited by 31
Coliphage MS2 containing 5-fluorouracil
Shimura, Y., Moses, R. E., & Nathans, D. (1965) · Journal of Molecular Biology · doi:10.1016/s0022-2836(65)80298-4 · Cited by 31
GRUNBERG‐MANAGO, M., & Michelson, A. M. (1964) · Biochimica et Biophysica Acta (BBA) - Specialized Section on Nucleic Acids and Related Subjects · doi:10.1016/0926-6550(64)90277-4 · Cited by 25
Preparative enzymic synthesis of nucleoside-5'-phosphates.
Giziewicz, J. B., & Shugar, D. (1975) · PubMed · Cited by 23
Polynucleotide Phosphorylase of Micrococcus lysodeikticus
Thanassi, N. M., & Singer, M. (1966) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99879-0 · Cited by 22
Characterization of the End Groups of RNA of Rous Sarcoma Virus
Keith, J., Gleason, M., & Fraenkel‐Conrat, H. (1974) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.71.11.4371 · Cited by 14
Self-citationEffects of bromine on the template and messenger specificities of polynucleotides
Means, G. E., & Fraenkel‐Conrat, H. (1971) · Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis · doi:10.1016/0005-2787(71)90030-x · Cited by 13
Self-citationKaiser, I. I., & Kwong, L. K. (1973) · FEBS Letters · doi:10.1016/0014-5793(73)80853-1 · Cited by 10
Cited by
Insight into the Mechanisms and Clinical Relevance of Antifungal Heteroresistance
Su, Y., Li, Y., Yi, Q., Xu, Y., Sun, T., & Li, Y. (2025) · Journal of Fungi · doi:10.3390/jof11020143 · Cited by 18
Metadata
- Authors
- Gleason, M. K., & Fraenkel-Conrat, H.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1976-05
- Volume
- 73
- Issue
- 5
- Pages
- 1528-1531
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC430330
- OpenAlex
- W2024860647
- Cited by
- 29
- References
- 21
- Citations by year
- 2025: 1 · 2018: 1 · 2016: 1
- FWCI
- 1.50
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Keywords
- 5-fluorouracil, RNA incorporation, HeLa cells, tobacco mosaic virus RNA, antitumor drug mechanism
- MeSH terms
- Cytosine, Flucytosine, Fluorouracil, HeLa Cells, Mutation, RNA, Messenger, RNA, Viral, Structure-Activity Relationship, Templates, Genetic, Tobacco Mosaic Virus
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