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Thermodynamic fluctuations in protein molecules.
Open accessAbstract
Apparently conflicting views of the physical nature of globular proteins, and other macromolecules, may be reconciled by consideration of the inevitable thermodynamic fluctuations inherent in microscopic systems. Discrete protein molecules, considered singly, undergo sizeable fluctuations in thermodynamic properties which are manifest in their stochastic properties. This is not incompatible with time-averaged studies of ensembles of proteins from which a more compact, rigid, and static view of these molecules may be obtained.
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Cited by
Protein states and proteinquakes.
Ansari, A., Berendzen, J., Bowne, S. F., Frauenfelder, H., Iben, I. E., Sauke, T. B., Shyamsunder, E., & Young, R. D. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.15.5000 · Cited by 828
Wei, G., Xi, W., Nussinov, R., & Ma, B. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00562 · Cited by 436
Ensemble-based characterization of unbound and bound states on protein energy landscape
Ruvinsky, A. M., Kirys, T., Tuzikov, A. V., & Vakser, I. A. (2013) · Protein Science · doi:10.1002/pro.2256 · Cited by 9
Metadata
- Authors
- Cooper, A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1976-08
- Volume
- 73
- Issue
- 8
- Pages
- 2740-2741
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2032168101
- Cited by
- 410
- References
- 0
- FWCI
- 4.42
- Type
- journal article
- Language
- en
- Open access
- green
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- Cooper, A. (1976). Thermodynamic fluctuations in protein molecules. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.73.8.2740
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