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Interferon, double-stranded RNA, and protein phosphorylation.
Open accessAbstract
We reported earlier that the addition of double-stranded RNA and ATP increases the endonuclease activity more in an extract of Ehrlich ascites tumor cells which have been treated with an interferon preparation than in a comparable extract from control cells. We report here that the addition of double-stranded RNA to an extract from Ehrlich ascites tumor cells which have been treated with an interferon preparation [or with the interferon inducer poly(I)-poly(C)] promotes the phosphorylation by [gamma-32P]ATP of at least two proteins: P1 (molecular weight of 64,000) and P2 (molecular weight of 37,000). Double-stranded RNA also promotes the phosphorylation of at least one (i.e., P1) of these two proteins in an extract from cells which have not been treated with interferon, but the extent of phosphorylation is much smaller. Double-stranded RNA which has been degraded by RNase III, or DNA, does not promote the phosphorylation.
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Citations
Cited by
Greengard, P. (1978) · Science · doi:10.1126/science.22932 · Cited by 965
Impact of Protein Kinase PKR in Cell Biology: from Antiviral to Antiproliferative Action
García, M. A., Gil, J., Ventoso, I., Guerra, S., Domingo, E., Rivas, C., & Esteban, M. (2006) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00027-06 · Cited by 818
Kerr, I. M., & Brown, R. E. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.1.256 · Cited by 787
Phosphorylation of initiation factor eIF-2 and the control of reticulocyte protein synthesis
Farrell, P. J., Balkow, K., Hunt, T., Jackson, R. J., & Trachsel, H. (1977) · Cell · doi:10.1016/0092-8674(77)90330-0 · Cited by 745
Synthesis in E. coli of a polypeptide with human leukocyte interferon activity
Nagata, S., Taira, H., Hall, A., Johnsrud, L., Streuli, M., Ecsödi, J., Boll, W., Cantell, K., & Weissmann, C. (1980) · Nature · doi:10.1038/284316a0 · Cited by 481
Metadata
- Authors
- Lebleu, B., Sen, G. C., Shaila, S., Cabrer, B., & Lengyel, P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1976-09
- Volume
- 73
- Issue
- 9
- Pages
- 3107-3111
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2066342343
- Cited by
- 319
- References
- 0
- FWCI
- 14.20
- Type
- journal article
- Language
- en
- Open access
- green
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- Lebleu, B., Sen, G. C., Shaila, S., Cabrer, B., & Lengyel, P. (1976). Interferon, double-stranded RNA, and protein phosphorylation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.73.9.3107
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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