The DOI matches its Crossref record.
Surface antigen in early differentiation.
Open accessAbstract
Addition of Fab fragments from rabbit antiserum to surface antigen F9 to 2-cell stage mouse embryos in culture does not alter cleavage; however, the addition prevents culture does not alter cleavage; however, the addition prevents the formation of compact morulae and blastocysts. A similar effect is observed when Fab fragments are added to already compact 8-cell stage or even older morulae, but disappears at the beginning of blastocoel formation. This effect is reversible: uncompact 30-cell embryos washed free of Fab become compact in a few hours, produce blastocysts, and upon reimplantation into pseudopregnant mothers can produce mice. Development is not altered by divalent anti-F9 antibodies, by Fab fragments from sera directed against other embryo surface antigens, or by succinyl concanavalin A.
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Citations
Cited by
Glycosphingolipids in Cellular Interaction, Differentiation, and Oncogenesis
Hakomori, S. (1981) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.50.070181.003505 · Cited by 1,644
Müller, K., & Gerisch, G. (1978) · Nature · doi:10.1038/274445a0 · Cited by 320
Cadherins in early neural development
Punovuori, K., Malaguti, M., & Lowell, S. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03815-9 · Cited by 39
Metadata
- Authors
- Kemler, R., Babinet, C., Eisen, H., & Jacob, F.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1977-10
- Volume
- 74
- Issue
- 10
- Pages
- 4449-4452
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2087688021
- Cited by
- 236
- References
- 0
- FWCI
- 7.41
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Surface antigen in early differentiation. https://app.cochat.ai/papers/10.1073/pnas.74.10.4449
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- Kemler, R., Babinet, C., Eisen, H., & Jacob, F. (1977). Surface antigen in early differentiation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.74.10.4449
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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