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Idiotypic-anti-idiotypic regulation of antibody synthesis in rabbits.
Open accessAbstract
Anti-ribonuclease antibodies (Ab1) of one rabbit were used to prepare in two other rabbits anti-idiotypic antibodies (Ab2) against them. Anti-idiotypic antibodies (Ab3) were prepared against Ab2 of one rabbit in two other rabbits that had the same phenotype as the former three for the allotypic a and b systems. After a rest period of 4 months, the latter two rabbits were immunized against ribonuclease. The antibodies produced (Ab1') crossreacted with the two anti-idiotypic sera (Ab2) against Ab1, showing an idiotypic similarity between anti-ribonuclease Ab1' and anti-ribonuclease Ab1. No such crossreaction was observed between the anti-idiotypic sera (Ab2) against Ab1 and any of the 12 unrelated antisera against ribonuclease that were tested. These results suggest (i) that rabbits, at least with the same allotypes, possess a closely related idiotypic repertoire; and (ii) that the immune system is a network of variable (V)-domains.
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Cited by
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Jerne, N. K., Roland, J., & Cazenave, P. A. (1982) · The EMBO Journal · doi:10.1002/j.1460-2075.1982.tb01154.x · Cited by 425
Self-citationA simple model for the immune network.
Parisi, G. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.1.429 · Cited by 104
Anergy in self-directed B lymphocytes: A statistical mechanics perspective
Agliari, E., Barra, A., Del Ferraro, G., Guerra, F., & Tantari, D. (2015) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2014.05.006 · Cited by 34
Metadata
- Authors
- Cazenave, P. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1977-11
- Volume
- 74
- Issue
- 11
- Pages
- 5122-5125
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2040616723
- Cited by
- 218
- References
- 0
- FWCI
- 19.98
- Type
- journal article
- Language
- en
- Open access
- green
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- Cazenave, P. A. (1977). Idiotypic-anti-idiotypic regulation of antibody synthesis in rabbits. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.74.11.5122
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