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Amino acid sequence of human platelet factor 4.
Open accessAbstract
Human platelet factor 4, a protein that binds heparin, has been purified to apparent homogeneity and the complete amino acid sequence of the protein has been determined. The 70-residue polypeptide chain contains no methionine, tryptophan, or phenylalanine, and contains only a single tyrosyl residue. The sequence analysis demonstrates a highly negatively charged amino-terminal region. The carboxyl-terminal region of the polypeptide is unusual in that it contains a repetitive clustering of positively charged and hydrophobic pairs of amino acids; preliminary evidence suggests that this domain may play a role in the binding of heparin.
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Cited by
Walz, A., Burgener, R., Car, B., Baggiolini, M., Kunkel, S. L., & Strieter, R. M. (1991) · The Journal of experimental medicine · doi:10.1084/jem.174.6.1355 · Cited by 353
Platelet chemokines and chemokine receptors, linking hemostasis, inflammation, and host defense
GEAR, A. R. L., & CAMERINI, D. (2003) · Microcirculation · doi:10.1038/sj.mn.7800198 · Cited by 317
A new genetic strategy for targeting microglia in development and disease
McKinsey, G. L., Lizama, C. O., Keown-Lang, A. E., Niu, A., Santander, N., Larpthaveesarp, A., Chee, E., Gonzalez, F. F., & Arnold, T. D. (2020) · eLife · doi:10.7554/elife.54590 · Cited by 176
Fujishima, S., Hoffman, A. R., Vu, T., Kim, K. J., Zheng, H., Daniel, D., Kim, Y., Wallace, E. F., Larrick, J. W., & Raffin, T. A. (1993) · Journal of Cellular Physiology · doi:10.1002/jcp.1041540305 · Cited by 151
Gupta, S. K., Hassel, T., & Singh, J. P. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.17.7799 · Cited by 141
Metadata
- Authors
- Deuel, T. F., Keim, P. S., Farmer, M., & Heinrikson, R. L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1977-06
- Volume
- 74
- Issue
- 6
- Pages
- 2256-2258
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2030344520
- Cited by
- 310
- References
- 0
- FWCI
- 15.67
- Type
- journal article
- Language
- en
- Open access
- green
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- Deuel, T. F., Keim, P. S., Farmer, M., & Heinrikson, R. L. (1977). Amino acid sequence of human platelet factor 4. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.74.6.2256
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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