The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Neuronal actions of endorphins and enkephalins among brain regions: a comparative microiontophoretic study.
Open accessAbstract
The brain peptides alpha- and beta-endorphin, leucine- and methionine-enkephalin, as well as the opiate normorphine, have been evaluated by microiontophoresis for their effects on neuronal activity in several regions of the rat brain. In cerebral cortex, brainstem, caudate nucleus, and thalamus, most responsive cells were inhibited by the peptides and by normorphine, while in hippocampus all responsive cells were excited. Both inhibitory and excitatory responses were blocked by the narcotic antagonist naloxone. Occurrence of responsive cells encountered in a particular region was loosely correlated with density of stereospecific opiate binding sites as reported by others. These results are consistent with the hypothesis that the endorphins and enkephalins may represent a new class of central neurotransmitters; among other functions, these peptides may play a role in the regulation of behavior and the expression of psychopharmacological agents such as the opiate alkaloids.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Identification of two related pentapeptides from the brain with potent opiate agonist activity
Hughes, J., Smith, T. W., Kosterlitz, H. W., Fothergill, L. A., Morgan, B. A., & Morris, H. R. (1975) · Nature · doi:10.1038/258577a0 · Cited by 3,806
Cited by
Cellular and molecular mechanisms of drug dependence
Koob, G. F., & Bloom, F. E. (1988) · Science · doi:10.1126/science.2903550 · Cited by 2,070
Self-citationOpioids excite dopamine neurons by hyperpolarization of local interneurons
Johnson, S., & North, R. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-02-00483.1992 · Cited by 1,637
Hippocampal GABAergic Inhibitory Interneurons
Pelkey, K. A., Chittajallu, R., Craig, M. T., Tricoire, L., Wester, J. C., & McBain, C. J. (2017) · Physiological Reviews · doi:10.1152/physrev.00007.2017 · Cited by 889
Mu, delta, and kappa opioid receptor mRNA expression in the rat CNS: An in situ hybridization study
Mansour, A., Fox, C. A., Burke, S., Meng, F., Thompson, R. C., Akil, H., & Watson, S. J. (1994) · Journal of Comparative Neurology · doi:10.1002/cne.903500307 · Cited by 870
The immunocytochemical localization of enkephalin in the central nervous system of the rat
Finley, J. C. W., Maderdrut, J. L., & Petrusz, P. (1981) · Journal of Comparative Neurology · doi:10.1002/cne.901980402 · Cited by 554
Metadata
- Authors
- Nicoll, R. A., Siggins, G. R., Ling, N., Bloom, F. E., & Guillemin, R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1977-06
- Volume
- 74
- Issue
- 6
- Pages
- 2584-2588
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2051120149
- Cited by
- 298
- References
- 1
- FWCI
- 9.01
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Neuronal actions of endorphins and enkephalins among brain regions: a comparative microiontophoretic study. https://app.cochat.ai/papers/10.1073/pnas.74.6.2584
- The paper
- Nicoll, R. A., Siggins, G. R., Ling, N., Bloom, F. E., & Guillemin, R. (1977). Neuronal actions of endorphins and enkephalins among brain regions: a comparative microiontophoretic study. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.74.6.2584
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
