The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Immunohistochemical analysis of peptide pathways possibly related to pain and analgesia: enkephalin and substance P.
Open accessAbstract
The distribution of Met-enkephalin- and substance P-immunoreactive neurons was studied by indirect immunofluorescence in some areas related to pain and analgesia. Met-enkephalin- and substance P-positive cell bodies and nerve terminals were observed in the periaqueductal central gray, the nucleus raphe magnus, the marginal layers and substantia gelatinosa of the spinal trigeminal nucleus, and the dorsal horn of the spinal cord. Lesion experiments suggest that Met-enkephalin neurons in the dorsal horn and possibly in the spinal trigeminal nucleus are interneurons or propriospinal neurons with nerve terminals in the laminae I and II of the cord and in the superficial layers of the spinal trigeminal nucleus, respectively. These areas are also very rich in substance P-positive nerve terminals, mainly representing central branches of primary afferent neurons. The present immunohistochemical-anatomical findings support the hypothesis that stimulation-produced analgesia is related to activation of spinal and spinal trigeminal enkephalin interneurons forming axo-axonic synapses with (substance P?) pain afferents in the superficial laminae of the dorsal horn and the spinal trigeminal nucleus. These interneurons may be activated by sensory fibers and by descending fibers from medullary stimulation sites. Transmitter substances in these descending fibers may be 5-hydroxytryptamine and substance P.
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Citations
Cites
Identification of two related pentapeptides from the brain with potent opiate agonist activity
Hughes, J., Smith, T. W., Kosterlitz, H. W., Fothergill, L. A., Morgan, B. A., & Morris, H. R. (1975) · Nature · doi:10.1038/258577a0 · Cited by 3,806
Liebeskind, J. C., Guilbaud, G., Besson, J.-M., & Oliveras, J.-L. (1973) · Brain Research · doi:10.1016/0006-8993(73)90748-8 · Cited by 439
Cited by
Endogenous Pain Control Systems: Brainstem Spinal Pathways and Endorphin Circuitry
Basbaum, A. I., & Fields, H. L. (1984) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.07.030184.001521 · Cited by 2,687
Functional anatomy of the basal ganglia. I. The cortico-basal ganglia-thalamo-cortical loop
Parent, A., & Hazrati, L.-N. (1995) · Brain Research Reviews · doi:10.1016/0165-0173(94)00007-c · Cited by 2,161
Johansson, O., Hökfelt, T., & Elde, R. P. (1984) · Neuroscience · doi:10.1016/0306-4522(84)90233-1 · Cited by 674
Self-citationEnkephalin-like immunoreactivity in gland cells and nerve terminals of the adrenal medulla
Schultzberg, M., Lundberg, J. M., Ho¨kfelt, T., Terenius, L., Brandt, J., Elde, R. P., & Goldstein, M. (1978) · Neuroscience · doi:10.1016/0306-4522(78)90137-9 · Cited by 555
Self-citationHerkenham, M. (1987) · Neuroscience · doi:10.1016/0306-4522(87)90268-5 · Cited by 520
Metadata
- Authors
- Hökfelt, T., Ljungdahl, A., Terenius, L., Elde, R., & Nilsson, G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1977-07
- Volume
- 74
- Issue
- 7
- Pages
- 3081-3085
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1978651683
- Cited by
- 887
- References
- 2
- FWCI
- 72.71
- Type
- journal article
- Language
- en
- Open access
- green
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- Hökfelt, T., Ljungdahl, A., Terenius, L., Elde, R., & Nilsson, G. (1977). Immunohistochemical analysis of peptide pathways possibly related to pain and analgesia: enkephalin and substance P. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.74.7.3081
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