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Amyloid protein SAA is associated with high density lipoprotein from human serum.
Open accessAbstract
Human serums contain a protein antigenically related to protein AA, the principal protein of a major class of amyloid substance. The serum antigen, SAA, occurs mainly in a high molecular weight form, 1 to 2 X 10(5). This work shows that the bulk of the SAA sediments at density 1.12 g/cm3 and floats at density 1.21 g/cm3, as does the high density lipoprotein HDL3. SAA is associated with the apolipoproteins ApoA-I and ApoA-II. The total cholesterol:total protein ratio of the fraction with density 1.12-1.21 g/cm3 is 0.2:1, consistent with that of SAA constituent of the HDL3 fraction into low molecular weight species of the order of 13,000. The quantity of SAA may vary from 0.1% or more of the total protein of HDL3.
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Cited by
Kontush, A., & Chapman, M. J. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.3.1 · Cited by 647
Breathnach, S. M. (1988) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(88)70001-8 · Cited by 615
Vascular inflammation and the renin-angiotensin system
Brasier, A. R., Recinos, A., & Eledrisi, M. S. (2002) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000021412.56621.a2 · Cited by 586
Sack, G. H. (2018) · Molecular Medicine · doi:10.1186/s10020-018-0047-0 · Cited by 499
Yao, C., Chen, G., Song, C., Keefe, J., Mendelson, M., Huan, T., Sun, B. B., Laser, A., Maranville, J. C., Wu, H., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05512-x · Cited by 431
Metadata
- Authors
- Benditt, E. P., & Eriksen, N.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1977-09
- Volume
- 74
- Issue
- 9
- Pages
- 4025-4028
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2130888600
- Cited by
- 430
- References
- 0
- FWCI
- 13.71
- Type
- journal article
- Language
- en
- Open access
- green
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- Benditt, E. P., & Eriksen, N. (1977). Amyloid protein SAA is associated with high density lipoprotein from human serum. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.74.9.4025
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