The DOI matches its Crossref record.
Role of contact inhibition in the regulation of receptor-mediated uptake of low density lipoprotein in cultured vascular endothelial cells.
Abstract
Bovine vascular endothelial cells during logarithmic growth bind, internalize, and degrade low density lipoprotein (LDL) via a receptor-mediated pathway. However, contact-inhibited (confluent) monolayers bind but do not internalize LDL. This is in contrast to aortic smooth muscle cells or endothelial cells that have lost the property of contact inhibition. These cells internalize and degrade LDL at both high and low cell densities. The LDL receptors of smooth muscle and sparse endothelial cells down-regulate in response to LDL. In contrast, normal endothelial cells at confluency show little response. When contact inhibition in endothelial monolayers was locally released by wounding, and LDL was present, only cells released from contact inhibition accumulated LDL cholesterol. In smooth muscle cells under the same conditions, the entire culture interiorized lipid. It thus appears that in endothelial cells, unlike smooth muscle cells, contact inhibition is the major factor regulating cellular uptake of LDL cholesteryl ester. Reversal of contact inhibition by wounding provides a mechanism by which the endothelium could be the primary initiator of the atherosclerotic plaque.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Growing endothelial cells in culture bind LDL.
“A number of different studies have confirmed that growing ECs in culture also bind LDL (Vlodavsky et al., 1978).”
From Upregulation of the low density lipoprotein receptor at the blood-brain barrier: intercommunications between brain capillary endothelial cells and astrocytes. (1994) · cites this paper as Vlodavsky et al., 1978
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
No references could be resolved yet.
Research works printed but not linked: 8
- [6]Gospodarowicz, D., Greenburg, G., Bialecki, H. & Zetter, B., (1977) in Cellular Control of Proliferation, ed. Freed, C. In Vitro 13, in press.
- [5]Gospodarowicz, D., Moran, J., Braun, D. & Birdwell, C. (1976) Proc. Natl. Acad. Sci. USA 73, 4120–4124.
- [18]Greep, R. O. (1966) Histology (McGraw Hill, New York), pp. 285-289.
- [20]Vasiliev, J. M., Gelfand, I. M., Domnina, L. V., Zacharova, O. S. & Ljubimov, A. V. (1975) Proc. Natl. Acad. Sci. USA 72, 719– 722.
- [19]Schubert, D., Harris, A. J., Heinemann, S., Kidokoro, Y. & Patrick, J. (1973) in Tissue Culture of the Nervous System, ed. Sato, G. (Plenum Press, New York), p. 58.
- [21]Oliver, J. M., Ukena, T. E. & Berlin, R. D. (1974) Proc. Natl. Acad. Sci. USA 71, 394–398.
- [23]Gospodarowicz, D., Vlodavsky, I. & Fielding, P. E. (1977) in International Congress of Birth Defects 5th, ed. Peereboom, T. (Excerpta Medica, Amsterdam), in press.
- [22]Raff, M. C. & De Petris, S. (1973) Fed. Proc. Fed. Am. Soc. Exp. Biol. 32, 48–54.
Cited by
Sorted by citations
The role of lipoproteins in steroidogenesis and cholesterol metabolism in steroidogenic glands
GWYNNE, J. T., & STRAUSS, J. F. (1982) · Endocrine Reviews · doi:10.1210/edrv-3-3-299 · Cited by 586
Dehouck, B., Dehouck, M. P., Fruchart, J. C., & Cecchelli, R. (1994) · The Journal of cell biology · doi:10.1083/jcb.126.2.465 · Cited by 240
Metadata
- Authors
- Vlodavsky, I., Fielding, P. E., Fielding, C. J., & Gospodarowicz, D.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1978-01
- Volume
- 75
- Issue
- 1
- Pages
- 356-360
- ISSN
- 0027-8424
- 1091-6490
- Cited by
- 116
- References
- 0
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
