The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Polymorphism of DNA sequence adjacent to human beta-globin structural gene: relationship to sickle mutation.
Open accessAbstract
Restriction endonuclease mapping of the human globin genes revealed a genetic variation in a Hpa I recognition site about 5000 nucleotides from the 3' end of the beta-globin structural gene. Instead of a normal 7.6-kilobase (kb) fragment which contains the beta-globin structural gene, 7.0-kb and 13.0-kb variants were detected. Both variants were found in people of African origin and were not detected in Asians or Caucasians. The 13.0-kb variant is frequently associated with the sickle hemoglobin mutation and may be useful for the prediction of the sickle cell gene in prenatal diagnosis. Polymorphism in a restriction enzyme site could be considered as a new class of genetic marker and may offer a new approach to linkage analysis and anthropological studies.
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Citations
Cites
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Self-citationIdentification of a Nondeletion Defect in α-Thalassemia
Kan, Y. W., Dozy, A. M., Trecartin, R., & Todd, D. (1977) · New England Journal of Medicine · doi:10.1056/nejm197711172972002 · Cited by 191
Self-citationPrenatal Diagnosis of α-Thalassemia
Kan, Y. W., Golbus, M. S., & Dozy, A. M. (1976) · New England Journal of Medicine · doi:10.1056/nejm197611182952104 · Cited by 145
Self-citationOrganization of human δ- and β-globin genes in cellular DNA and the presence of intragenic inserts
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Self-citation
Cited by
Saiki, R. K., Scharf, S., Faloona, F., Mullis, K. B., Horn, G. T., Erlich, H. A., & Arnheim, N. (1985) · Science · doi:10.1126/science.2999980 · Cited by 8,956
Identification of the Cystic Fibrosis Gene: Genetic Analysis
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Wahl, G. M., Stern, M., & Stark, G. R. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.8.3683 · Cited by 3,247
Genetic Mapping in Human Disease
Altshuler, D., Daly, M. J., & Lander, E. S. (2008) · Science · doi:10.1126/science.1156409 · Cited by 1,452
Genetic variation in microRNA networks: the implications for cancer research
Ryan, B. M., Robles, A. I., & Harris, C. C. (2010) · Nature Reviews Cancer · doi:10.1038/nrc2867 · Cited by 1,257
Metadata
- Authors
- Kan, Y. W., & Dozy, A. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1978-11
- Volume
- 75
- Issue
- 11
- Pages
- 5631-5635
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2049586830
- Cited by
- 801
- References
- 9
- FWCI
- 30.13
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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