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Chemotactic attraction of human fibroblasts to type I, II, and III collagens and collagen-derived peptides.
Open accessAbstract
The chemotactice response of human dermal fibroblasts of type I, II, and III human collagens and collagen-derived peptides was quantitated by an in vitro assay. All three native human collagens and constituent alpha chains can serve as chemoattractants for fibroblasts in vitro. When type I, II, and III collagens were digested by bacterial collagenase, the resulting peptides were also chemotactic. In addition, synthetic di- and tripeptides containing hydroxyproline were also chemotactic for fibroblasts. Since collagen is degraded and remodeled at sites of tissue injury and inflammation, these findings suggest that collagen and collagen-degradation peptides might function as chemotactic stimuli for fibroblasts in vivo and attract these cells to effect repair of damaged tissue.
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Citations
Cited by
Collagen-Based Biomaterials for Tissue Engineering Applications
Parenteau-Bareil, R., Gauvin, R., & Berthod, F. (2010) · Materials · doi:10.3390/ma3031863 · Cited by 1,256
Collagen-based biomaterials for wound healing
Chattopadhyay, S., & Raines, R. T. (2014) · Biopolymers · doi:10.1002/bip.22486 · Cited by 1,041
Demidova-Rice, T. N., Hamblin, M. R., & Herman, I. M. (2012) · Advances in Skin & Wound Care · doi:10.1097/01.asw.0000416006.55218.d0 · Cited by 721
Induction of tenascin in healing wounds
Mackie, E. J., Halfter, W., & Liverani, D. (1988) · The Journal of cell biology · doi:10.1083/jcb.107.6.2757 · Cited by 555
Chevallay, B., & Herbage, D. (2000) · Medical & Biological Engineering & Computing · doi:10.1007/bf02344779 · Cited by 403
Metadata
- Authors
- Postlethwaite, A. E., Seyer, J. M., & Kang, A. H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1978-02
- Volume
- 75
- Issue
- 2
- Pages
- 871-875
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2084653777
- Cited by
- 730
- References
- 0
- FWCI
- 38.82
- Type
- journal article
- Language
- en
- Open access
- green
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- Postlethwaite, A. E., Seyer, J. M., & Kang, A. H. (1978). Chemotactic attraction of human fibroblasts to type I, II, and III collagens and collagen-derived peptides. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.75.2.871
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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