The DOI matches its Crossref record.
The intervening sequence of a mouse beta-globin gene is transcribed within the 15S beta-globin mRNA precursor.
Open accessAbstract
Mouse beta-globin in encoded in a discontinuous structural gene interrupted by a 550-base pair intervening sequence of DNA. Correspondingly, the mature beta-globin mRNA appears to be synthesized via a 15S precursor, the length of which roughly equals the total length of the coding and intervening sequences of the beta-globin gene. Using the electron microscope to visualize hybrid structures formed between this gene and the purified 15S beta-globin mRNA precursor, we show that the intervening sequence is present within the larger precursor molecule. This finding suggests that the precursor mRNA is processed through the removal and rejoining of internal RNA sequences.
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Citations
Cited by
Weaver, R. F., & Weissmann, C. (1979) · Nucleic Acids Research · doi:10.1093/nar/7.5.1175 · Cited by 1,251
Self-citationBreathnach, R., Benoist, C., O'Hare, K., Gannon, F., & Chambon, P. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.10.4853 · Cited by 1,123
A cDNA cloning vector that permits expression of cDNA inserts in mammalian cells.
Okayama, H., & Berg, P. (1983) · Molecular and Cellular Biology · doi:10.1128/mcb.3.2.280 · Cited by 933
Human β-globin pre-mRNA synthesized in vitro is accurately spliced in xenopus oocyte nuclei
Green, M. R., Maniatis, T., & Melton, D. A. (1983) · Cell · doi:10.1016/0092-8674(83)90054-5 · Cited by 481
Transcription and processing of intervening sequences in yeast tRNA genes
Knapp, G., Beckmann, J. S., Johnson, P. F., Fuhrman, S. A., & Abelson, J. (1978) · Cell · doi:10.1016/0092-8674(78)90109-5 · Cited by 324
Metadata
- Authors
- Tilghman, S. M., Curtis, P. J., Tiemeier, D. C., Leder, P., & Weissmann, C.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1978-03
- Volume
- 75
- Issue
- 3
- Pages
- 1309-1313
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2041774127
- Cited by
- 242
- References
- 0
- FWCI
- 32.97
- Type
- journal article
- Language
- en
- Open access
- green
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- Tilghman, S. M., Curtis, P. J., Tiemeier, D. C., Leder, P., & Weissmann, C. (1978). The intervening sequence of a mouse beta-globin gene is transcribed within the 15S beta-globin mRNA precursor. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.75.3.1309
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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