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Cited by 305

The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.

Sodium-calcium ion exchange in cardiac membrane vesicles.

Open access
Reeves, J P, Sutko, J L·1979·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.76.2.590
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Abstract

Membrane vesicles isolated from rabbit ventricular tissue rapidly accumulated Ca2+ when an outwardly directed Na+ gradient was formed across the vesicle membrane. Vesicles loaded internally with K+ showed only 10% of the Ca2+ uptake activity observed with Na+-loaded vesicles. Dissipation of the Na+ gradient with the monovalent cation exchange ionophores nigericin or narasin caused a rapid decline in Ca2+ uptake activity. The Ca2+-ionophore A23187 inhibited Ca2+ uptake by Na+-loaded vesicles and enhanced the rate of Ca2+ loss from the vesicles after uptake. Efflux of preaccumulated Ca2+ from the vesicles was stimulated 30-fold by the presence of 50 mM Na+ in the external medium. Na+-dependent uptake and efflux of Ca2+ were both inhibited by La3+. The results indicate that cardiac membrane vesicles exhibit Na+-Ca2+ exchange activity. Fractionation of the vesicles by density gradient centrifugation revealed a close correspondence between Na+-Ca2+ exchange activity and specific ouabain-binding activity among the various fractions. This relationship suggests that the observed Na+-Ca2+ exchange activity derives from the sarcolemmal membranes within the vesicle preparation.

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Metadata

Authors
Reeves, J. P., & Sutko, J. L.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
1979-02
Volume
76
Issue
2
Pages
590-594
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.76.2.590
OpenAlex
W2082825600
Cited by
305
References
14
FWCI
12.26
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Sodium-calcium ion exchange in cardiac membrane vesicles. https://app.cochat.ai/papers/10.1073/pnas.76.2.590
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Reeves, J. P., & Sutko, J. L. (1979). Sodium-calcium ion exchange in cardiac membrane vesicles. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.76.2.590

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.