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Inactivation of Ca conductance dependent on entry of Ca ions in molluscan neurons.
Open accessAbstract
Inactivation of the Ca channel of Aplysia neurons was studied in the absence of potassium current in cells that were cesium-loaded with the aid of the ionophore nystatin. Inactivation was substantially decreased by methods that limited Ca entry. Depolarizations commensurate with the equilibrium potential of Ca resulted in minimal inactivation. Replacement of extracellular Ca by Ba also decreased inactivation. It is concluded that inactivation of the Ca channel is a function of the extent of Ca entry rather than membrane potential, thus differing fundamentally from the purely voltage-dependent mechanism for sodium inactivation.
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Cited by
Sodium and calcium channels in bovine chromaffin cells
Fenwick, E. M., Marty, A., & Neher, E. (1982) · The Journal of Physiology · doi:10.1113/jphysiol.1982.sp014394 · Cited by 961
A Classification of Antiarrhythmic Actions Reassessed After a Decade of New Drugs
WILLIAMS, E. M. V. (1984) · The Journal of Clinical Pharmacology · doi:10.1002/j.1552-4604.1984.tb01822.x · Cited by 818
Eckert, R., & Chad, J. E. (1984) · Progress in Biophysics and Molecular Biology · doi:10.1016/0079-6107(84)90009-9 · Cited by 608
Excitatory synaptic interactions between CA3 neurones in the guinea‐pig hippocampus.
Miles, R., & Wong, R. K. (1986) · The Journal of Physiology · doi:10.1113/jphysiol.1986.sp016055 · Cited by 503
An enzymatic mechanism for calcium current inactivation in dialysed Helix neurones.
Chad, J. E., & Eckert, R. (1986) · The Journal of Physiology · doi:10.1113/jphysiol.1986.sp016206 · Cited by 406
Metadata
- Authors
- Tillotson, D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1979-03
- Volume
- 76
- Issue
- 3
- Pages
- 1497-1500
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2045544906
- Cited by
- 392
- References
- 0
- FWCI
- 13.79
- Type
- journal article
- Language
- en
- Open access
- green
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- Tillotson, D. (1979). Inactivation of Ca conductance dependent on entry of Ca ions in molluscan neurons. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.76.3.1497
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