The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Purification of human platelet-derived growth factor.
Open accessAbstract
Human platelets contain a polypeptide growth factor that stimulates the proliferation of connective tissue cells. Purification of this platelet-derived growth factor (PDGF) was accomplished by heat (100 degrees C) treatment of washed platelets and subsequent ion-exchange chromatography, gel filtration in 1 M acetic acid, isoelectric focusing, and preparative sodium dodecyl sulfate/polyacrylamide gel electrophoresis. PDGF has an isoelectric point of 9.8 and a molecular weight ranging from 13,000 to 16,000 as judged by gel filtration in 1 M acetic acid or analytical sodium dodecyl sulfate gel electrophoresis under reducing conditions. The specific activity of the purified PDGF is 20 million times greater than that found in unfractionated human serum. Purified PDGF stimulates replicative DNA synthesis and cell proliferation in quiescent density-arrested cultures of BALB/c 3T3 cells at concentrations of 1 ng/ml (0.1 nM).
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Citations
Cites
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
Cited by
Doolittle, R. F., Hunkapiller, M. W., Hood, L. E., Devare, S. G., Robbins, K. C., Aaronson, S. A., & Antoniades, H. N. (1983) · Science · doi:10.1126/science.6304883 · Cited by 1,536
Self-citationPLATELET-DERIVED GROWTH FACTOR
Ross, R. (1989) · The Lancet · doi:10.1016/s0140-6736(89)92760-8 · Cited by 940
Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and protein
Kruijer, W., Cooper, J. A., Hunter, T., & Verma, I. M. (1984) · Nature · doi:10.1038/312711a0 · Cited by 916
Growth factors: Mechanism of action and relation to oncogenes
Heldin, C.-H., & Westermark, B. (1984) · Cell · doi:10.1016/0092-8674(84)90296-4 · Cited by 854
Characterization of human bone marrow fibroblast colony-forming cells (CFU-F) and their progeny
Castro-Malaspina, H., Gay, R., Resnick, G., Kapoor, N., Meyers, P., Chiarieri, D., McKenzie, S., Broxmeyer, H., & Moore, M. (1980) · Blood · doi:10.1182/blood.v56.2.289.289 · Cited by 852
Metadata
- Authors
- Antoniades, H. N., Scher, C. D., & Stiles, C. D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1979-04
- Volume
- 76
- Issue
- 4
- Pages
- 1809-1813
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2070351900
- Cited by
- 583
- References
- 1
- FWCI
- 41.91
- Type
- journal article
- Language
- en
- Open access
- green
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- Antoniades, H. N., Scher, C. D., & Stiles, C. D. (1979). Purification of human platelet-derived growth factor. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.76.4.1809
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
