Apolipoproteins in human cerebrospinal fluid.
Open accessAbstract
The presence of apolipoproteins A-I, E, C-II, and C-III and the absence of apolipoprotein B was demonstrated in human cerebrospinal fluid. The concentration of apolipoproteins was measured by electroimmunoassay. Apolipoproteins E, C-II, and C-III were present in cerebrospinal fluid at 3--5% of their concentration in plasma; the cerebrospinal fluid level of apolipoprotein A-I was 0.4%. Most of the cerebrospinal fluid apolipoproteins were present in the rho less than 1.21 g/ml lipoprotein fraction. The major apolipoporteins of cerebrospinal fluid are E and A-I. The possible mechanism of transfer and the physiological and pathophysiological role of apolipoproteins in cerebrospinal fluid are postulated.
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All ApoA1 in the central nervous system traverses from the periphery.
“However, all ApoA1 in the CNS traverses from the periphery [19].”
From Sterol and lipid analyses identifies hypolipidemia and apolipoprotein disorders in autism associated with adaptive functioning deficits (2021) · cites this paper as [19]
The Results identify apo A-I in cerebrospinal fluid, and the Discussion considers transfer of apolipoproteins from plasma as a possibility. But the Discussion says the mechanisms can only be postulated and does not establish that all CNS apo A-I comes from the periphery. (LLM, conf=0.88)
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References 27 · Cited by 282
Research works printed but not linked: 5
- [4]Chajek, T. & Fielding, C. J. (1978) Proc. Natl. Acad. Sci. USA 75, 3445–3449.
- [10]Roheim, P. S., Edelstein, D. & Pinter, G. G. (1976) Proc. Natl. Acad. Sci. USA 73, 1757–1760.
- [17]Ouchterlony, O. (1968) in Handbook of Immunodiffusion and Immunoelectrophoresis (Ann Arbor Science Publisher Inc., Ann Arbor, MI), pp. 21–31.
- [21]Maizel, J. V., Jr. (1971) in Methods of Virology, eds. Mormorosch, K., Koprowski, H., (Academic, New York), Vol. 5, pp. 179– 246.
- [28]Mahley, R. W. (1978) in Disturbances in Lipid and Lipoprotein Metabolism, eds. Dietschy, F. M., Gotto, A. M. & Ontko, J. A. (Am. Physiol. Soc., Bethesda, MD), pp. 181–197.
- Authors
- Roheim, P. S., Carey, M., Forte, T., & Vega, G. L.
- Affiliations
- Louisiana State University (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1979-09
- Volume
- 76
- Issue
- 9
- Pages
- 4646-4649
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC411636
- OpenAlex
- W2082336678
- Cited by
- 282
- References
- 27
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 6 · 2023: 3 · 2022: 7 · 2021: 3 · 2020: 6 · 2019: 8 · 2018: 4 · 2017: 4 · 2016: 5 · 2015: 5 · 2014: 3 · 2013: 3 · 2012: 6
- FWCI
- 0.14
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Keywords
- apolipoproteins, cerebrospinal fluid, apolipoprotein A-I, apolipoprotein E, apolipoprotein C-II, apolipoprotein C-III, apolipoprotein B, lipoprotein fractions
- MeSH terms
- Apolipoproteins, Biological Transport, Blood-Brain Barrier, Humans, Lipoproteins, Molecular Weight, Protein Conformation
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