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The inverted repeat as a recognizable structural feature in supercoiled DNA molecules.
Open accessAbstract
The single-strand-specific endonuclease S1 from Aspergillus oryzae introduces highly selective cleavages into supercoiled covalently closed circular DNA molecules, but not into their previously linearized counterparts. The cleavage sites are inverted repeats of unit length between 9 and 13 base pairs, separated by a nonrepetitious 2-6 base pairs. Such regions may adopt hairpin or similar structures stabilized by the negative superhelix density and may constitute recognition sites for cellular proteins.
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Citations
Cited by
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Balbás, P., Soberón, X., Merino, E., Zurita, M., Lomeli, H., Valle, F., Flores, N., & Bolivar, F. (1986) · Gene · doi:10.1016/0378-1119(86)90307-0 · Cited by 310
Voineagu, I., Narayanan, V., Lobachev, K. S., & Mirkin, S. M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804510105 · Cited by 269
Travers, A., & Muskhelishvili, G. (2015) · The FEBS Journal · doi:10.1111/febs.13307 · Cited by 277
Metadata
- Authors
- Lilley, D. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1980-11
- Volume
- 77
- Issue
- 11
- Pages
- 6468-6472
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2051058497
- Cited by
- 514
- References
- 0
- FWCI
- 14.12
- Type
- journal article
- Language
- en
- Open access
- green
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- Lilley, D. M. (1980). The inverted repeat as a recognizable structural feature in supercoiled DNA molecules. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.77.11.6468
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