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A phospholipase A2 inhibitory protein in rabbit neutrophils induced by glucocorticoids.
Open accessAbstract
When rabbit peritoneal neutrophils were treated with glucocorticoids, their chemotactic response to stimulation by the chemoattractant fMet-Leu-Phe was markedly reduced. Preincubation of cells with glucocorticoids also decreased phospholipase A2 (phosphatide 2-acylhydrolase, EC 3.1.1.4) activity in situ as measured by the release of [1-14C]arachidonic acid previously incorporated into phospholipids. The inhibitory potencies of glucocorticoids on phospholipase A2 activity correlated well with their anti-inflammatory activities and their abilities to bind to glucocorticoid receptors. Inhibitors of RNA and protein synthesis suppressed the inhibitory effect of glucocorticoids on phospholipase A2 activity. Digestion of the glucocorticoid-treated cells by Pronase overcame the inhibitory activity. Phospholipase A2 activity induced by Ca2+ ionophore A23187 was not affected by Pronase treatment. Gel filtration of proteins from neutrophil membranes labeled with [3H]lysine showed an induction of protein(s) (about 40,000 daltons) after glucocorticoid treatment. This protein inhibited a partially purified pancreatic phospholipase A2 and reduced the peptide-initiated chemotactic response of neutrophils.
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Cited by
Immunoregulatory Feedback Between Interleukin-1 and Glucocorticoid Hormones
Besedovsky, H., del Rey, A., Sorkin, E., & Dinarello, C. A. (1986) · Science · doi:10.1126/science.3014662 · Cited by 1,519
Stress hormones: their interaction and regulation
Axelrod, J., & Reisine, T. D. (1984) · Science · doi:10.1126/science.6143403 · Cited by 1,527
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Metadata
- Authors
- Hirata, F., Schiffmann, E., Venkatasubramanian, K., Salomon, D., & Axelrod, J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1980-05
- Volume
- 77
- Issue
- 5
- Pages
- 2533-2536
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2026144498
- Cited by
- 829
- References
- 0
- FWCI
- 19.00
- Type
- journal article
- Language
- en
- Open access
- green
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- Hirata, F., Schiffmann, E., Venkatasubramanian, K., Salomon, D., & Axelrod, J. (1980). A phospholipase A2 inhibitory protein in rabbit neutrophils induced by glucocorticoids. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.77.5.2533
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