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Subclasses of external adenosine receptors.
Open accessAbstract
Cell surface adenosine receptors mediate either stimulation or inhibition of adenylate cyclase activity [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1], and the receptors that mediate these different responses can be discriminated with selected adenosine analogs. 5'-N-Ethylcarboxamide-adenosine is a more potent agonist at stimulatory receptors (Ra) than is N6-phenylisopropyladenosine, whereas the reverse potency order is seen with inhibitory receptors (Ri). The potency of adenosine is intermediate between the potencies of these two analogs. The relative potencies of adenosine receptor agonists are maintained in physiological responses in intact cells, such as steroidogenesis and inhibition of lipolysis. As with adrenergic receptors, subclasses of adenosine receptors differ functionally and pharmacologically.
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Cited by
International Union of Pharmacology. XXV. Nomenclature and Classification of Adenosine Receptors
Fredholm, B. B., IJzerman, A. P., Jacobson, K. A., Klotz, K.-N., & Linden, J. (2001) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01511-4 · Cited by 2,585
Nomenclature and classification of purinoceptors.
Fredholm, B. B., Abbracchio, M. P., Burnstock, G., Daly, J. W., Harden, T. K., Jacobson, K. A., Leff, P., & Williams, M. (1994) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06782-1 · Cited by 1,585
Adenosine Receptors as Therapeutic Targets
Jacobson, K. A., & Gao, Z.-G. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd1983 · Cited by 1,431
Purinoceptors: Are there families of P2X and P2Y purinoceptors?
Abbracchio, M. P., & Burnstock, G. (1994) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(94)00048-4 · Cited by 1,083
The Physiological Role of Adenosine In The Central Nervous System
Dunwiddie, T. V. (1985) · International Review of Neurobiology · doi:10.1016/s0074-7742(08)60556-5 · Cited by 623
Metadata
- Authors
- Londos, C., Cooper, D. M., & Wolff, J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1980-05
- Volume
- 77
- Issue
- 5
- Pages
- 2551-2554
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2007462827
- Cited by
- 1,081
- References
- 0
- FWCI
- 20.23
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Londos, C., Cooper, D. M., & Wolff, J. (1980). Subclasses of external adenosine receptors. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.77.5.2551
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
