The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
DNA-damaging agents stimulate gene expression at specific loci in Escherichia coli.
Open accessAbstract
Operon fusions in Escherichia coli were obtained that showed increased beta-galactosidase expression in response to treatment with the DNA-damaging agent mitomycin C. These fusions were generated by using the Mud(ApR, lac) vector [Casadaban, M.J. & Cohen, S.N. (1979) Proc. Natl. Acad. Sci. USA 76, 4530-4533] to insert the lactose structural genes randomly into the bacterial chromosome. Induction of beta-galactosidase in these strains, which carried fusions of lac to these din (damage-inducible) loci, was (i) triggered by UV light as well as by mitomycin C and (ii) abolished by either a recA- or a lexA- mutation. Similar characteristics of induction were observed when the lactose genes were fused to a prophage lambda promoter by using Mud(ApR, lac). These results indicate that E. coli contains a set of genes that, like prophage lambda genes, are expressed in response to DNA-damaging agents and regulated by the recA and lexA gene products. These din genes map at five bacterial loci. One din::Mud(ApR, lac) insertion results in a UV-sensitive phenotype and may be within the uvrA transcriptional unit.
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Cites
Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli
Witkin, E. M. (1976) · Bacteriological Reviews · doi:10.1128/br.40.4.869-907.1976 · Cited by 1,862
Casadaban, M. J., & Cohen, S. N. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.9.4530 · Cited by 924
Escherichia coli recA gene product inactivates phage lambda repressor.
Roberts, J. W., Roberts, C. W., & Craig, N. L. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.10.4714 · Cited by 302
George, J., Castellazzi, M., & Buttin, G. (1975) · PubMed · Cited by 245
Mount, D. W. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.1.300 · Cited by 230
Maximizing gene expression on a plasmid using recombination in vitro
Backman, K., & Ptashne, M. (1978) · Cell · doi:10.1016/0092-8674(78)90138-1 · Cited by 198
Identification of the recA ( tif ) gene product of Escherichia coli
Gudas, L. J., & Mount, D. W. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.12.5280 · Cited by 177
Walker, G. C. (1977) · Molecular and General Genetics MGG · doi:10.1007/bf00264945 · Cited by 172
Self-citationProtein X is the product of the recA gene of Escherichia coli.
McEntee, K. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.12.5275 · Cited by 164
Seeberg, E. C. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.6.2569 · Cited by 140
Cited by
Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli
Walker, G. C. (1984) · Microbiological Reviews · doi:10.1128/mmbr.48.1.60-93.1984 · Cited by 1,770
Self-citationThe SOS regulatory system of Escherichia coli
Little, J. W., & Mount, D. W. (1982) · Cell · doi:10.1016/0092-8674(82)90085-x · Cited by 1,489
Types and origins of bacterial membrane vesicles
Toyofuku, M., Nomura, N., & Eberl, L. (2019) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0112-2 · Cited by 1,303
Courcelle, J., Khodursky, A., Peter, B., Brown, P. O., & Hanawalt, P. C. (2001) · Genetics · doi:10.1093/genetics/158.1.41 · Cited by 853
PROTEASES AND THEIR TARGETS IN ESCHERICHIA COLI
Gottesman, S. (1996) · Annual Review of Genetics · doi:10.1146/annurev.genet.30.1.465 · Cited by 717
Metadata
- Authors
- Kenyon, C. J., & Walker, G. C.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1980-05
- Volume
- 77
- Issue
- 5
- Pages
- 2819-2823
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2001949463
- Cited by
- 535
- References
- 10
- FWCI
- 32.28
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
