The DOI matches its Crossref record.
Preferential neurotoxicity of colchicine for granule cells of the dentate gyrus of the adult rat.
Open accessAbstract
Injections of 5-7 microgram (6-9 nmol) of colchicine into the dentate gyrus of the hippocampus of mature rats result in widespread destruction of dentate granule cells with little, if any, damage to other cell populations, including hippocampal pyramidal cells. Selective destruction of dentate granule cells is also observed after intraventricular injections. The destructive effects of colchicine appear as soon as 12 hr after the injection and lead to the disappearance of the granule cells over a period of days. Whereas the effects on nongranule cell populations in the hippocampus appear to be reversed by approximately 11 days after injection, the granule cells are almost completely absent at long intervals after injection. At the long postinjection survival intervals the disappearance of the granule cells is accompanied by elimination of their terminal projections, the mossy fibers, as revealed by Timm staining for heavy metals. Because the preferential neurotoxic effects of colchicine do not result in morbidity or obvious behavioral debilitation, the toxicity may prove useful for studying the functional consequences of removing specific cell populations in the central nervous system.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Shigemoto, R., Kinoshita, A., Wada, E., Nomura, S., Ohishi, H., Takada, M., Flor, P. J., Neki, A., Abe, T., Nakanishi, S., et al. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-19-07503.1997 · Cited by 1,116
Dissociating hippocampal subregions: A double dissociation between dentate gyrus and CA1
Gilbert, P. E., Kesner, R. P., & Lee, I. (2001) · Hippocampus · doi:10.1002/hipo.1077 · Cited by 641
Sutherland, R. J., Whishaw, I. Q., & Kolb, B. (1983) · Behavioural Brain Research · doi:10.1016/0166-4328(83)90188-2 · Cited by 592
Spatial mapping: definitive disruption by hippocampal or medial frontal cortical damage in the rat
Sutherland, R. J., Kolb, B., & Whishaw, I. Q. (1982) · Neuroscience Letters · doi:10.1016/0304-3940(82)90032-5 · Cited by 537
McNaughton, B. L., Barnes, C. A., Meltzer, J., & Sutherland, R. J. (1989) · Experimental Brain Research · doi:10.1007/bf00248904 · Cited by 388
Metadata
- Authors
- Goldschmidt, R. B., & Steward, O.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1980-05
- Volume
- 77
- Issue
- 5
- Pages
- 3047-3051
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2064729669
- Cited by
- 190
- References
- 0
- FWCI
- 4.37
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Preferential neurotoxicity of colchicine for granule cells of the dentate gyrus of the adult rat. https://app.cochat.ai/papers/10.1073/pnas.77.5.3047
- The paper
- Goldschmidt, R. B., & Steward, O. (1980). Preferential neurotoxicity of colchicine for granule cells of the dentate gyrus of the adult rat. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.77.5.3047
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
