The DOI matches its Crossref record.
Inherited structural polymorphism of the fourth component of human complement.
Open accessAbstract
Human fourth component of complement (C4) was found to be highly polymorphic by agarose gel electrophoresis of neuraminidase-treated plasma. The system allows clear-cut separation of the products of the two C4 genetic loci, C4A (acidic or Rodgers) and C4B (basic or Chido). There are at least six structural variants and a deletion allele at the C4A locus and two structural variants and a deletion allele at the C4B locus. Close linkage with no crossovers was found between the two C4 loci, allowing the definition of C4AB haplotypes, and between C4 haplotypes and the C2 and BF loci of the human histocompatibility complex. Nine C4 haplotypes, each with a frequency of 0.005 or more in Caucasians, were found. These studies provide direct evidence for two distinct but closely linked genetic loci for human C4 in the major histocompatibility complex on the short arm of chromosome 6.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Genetic Prediction of Nonresponse to Hepatitis B Vaccine
Alper, C. A., Kruskall, M. S., Marcus-Bagley, D., Craven, D. E., Katz, A. J., Brink, S. J., Dienstag, J. L., Awdeh, Z., & Yunis, E. J. (1989) · New England Journal of Medicine · doi:10.1056/nejm198909143211103 · Cited by 401
Self-citationThe Fine-Scale and Complex Architecture of Human Copy-Number Variation
Perry, G. H., Ben-Dor, A., Tsalenko, A., Sampas, N., Rodriguez-Revenga, L., Tran, C. W., Scheffer, A., Steinfeld, I., Tsang, P., Yamada, N. A., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2007.12.010 · Cited by 346
A comparison of the properties of two classes, C4A and C4B, of the human complement component C4
Law, S. K., Dodds, A. W., & Porter, R. R. (1984) · The EMBO Journal · doi:10.1002/j.1460-2075.1984.tb02052.x · Cited by 303
Yu, C. Y., Belt, K. T., Giles, C. M., Campbell, R. D., & Porter, R. R. (1986) · The EMBO Journal · doi:10.1002/j.1460-2075.1986.tb04582.x · Cited by 221
Blanchong, C. A., Zhou, B., Rupert, K. L., Chung, E. K., Jones, K. N., Sotos, J. F., Zipf, W. B., Rennebohm, R. M., & Yu, C. Y. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.12.2183 · Cited by 187
Metadata
- Authors
- Awdeh, Z. L., & Alper, C. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1980-06
- Volume
- 77
- Issue
- 6
- Pages
- 3576-3580
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2088883442
- Cited by
- 483
- References
- 0
- FWCI
- 10.10
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Inherited structural polymorphism of the fourth component of human complement. https://app.cochat.ai/papers/10.1073/pnas.77.6.3576
- The paper
- Awdeh, Z. L., & Alper, C. A. (1980). Inherited structural polymorphism of the fourth component of human complement. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.77.6.3576
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
