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A specific transcription factor that can bind either the 5S RNA gene or 5S RNA.
Open accessAbstract
5S ribosomal RNA specifically inhibits transcription of cloned repeating units of 5S DNA in a nuclear extract of Xenopus oocytes. The inhibition can be explained by the interaction of 5S RNA with a transcription factor that binds specifically to a control region located within the 5S RNA gene. This transcription factor is identical to an abundant cytoplasmic protein that is known to be complexed with 5S RNA in immature Xenopus oocytes. Thus the presence of large amounts of this protein in these cells can account for both the high rate of synthesis and the subsequent storage of 5S RNA to ribosome synthesis.
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Cited by
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Sukhatme, V. P., Cao, X., Chang, L. C., Tsai-Morris, C.-H., Stamenkovich, D., Ferreira, P. C. P., Cohen, D. R., Edwards, S. A., Shows, T. B., Curran, T., et al. (1988) · Cell · doi:10.1016/0092-8674(88)90485-0 · Cited by 1,250
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Page, D. C., Mosher, R., Simpson, E. M., Fisher, E. M. C., Mardon, G., Pollack, J., McGillivray, B., de la Chapelle, A., & Brown, L. G. (1987) · Cell · doi:10.1016/0092-8674(87)90595-2 · Cited by 832
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Klug, A. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-010909-095056 · Cited by 710
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Long, Y., Wang, X., Youmans, D. T., & Cech, T. R. (2017) · Science Advances · doi:10.1126/sciadv.aao2110 · Cited by 689
Metadata
- Authors
- Pelham, H. R., & Brown, D. D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1980-07
- Volume
- 77
- Issue
- 7
- Pages
- 4170-4174
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2007490638
- Cited by
- 504
- References
- 0
- FWCI
- 14.81
- Type
- journal article
- Language
- en
- Open access
- green
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- Pelham, H. R., & Brown, D. D. (1980). A specific transcription factor that can bind either the 5S RNA gene or 5S RNA. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.77.7.4170
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
