The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Elongation of displacement-loop strands in human and mouse mitochondrial DNA is arrested near specific template sequences.
Open accessAbstract
Animal mitochondrial DNA (mtDNA) maintains a displacement loop (D loop) at the heavy strand origin of replication. These D loops represent sharply limited synthesis of heavy strands and provide a unique opportunity to examine the termination of DNA synthesis. Direct sizing at the nucleotide level indicates that the 3' ends of D-loop strands of human and mouse mtDNA are discrete and map within three to five nucleotides on the complementary template strand. In the case of human mtDNA, there is a single trinucleotide stop point 51-53 nucleotides downstream from a 15-nucleotide template sequence (3'T-A-A-C-C-C-A-A-A-A-A-T-A-C-A 5') which is repeated four times in the mouse mtDNA D-loop region 3'(T-A-A-Py-Py-A-A-A-T-T-A-C-A 5'). The stop points of the five major mouse D-loop strands are 24-63 nucleotides downstream from the four repeated template sequences. These results suggest that the arrest of D-loop strand elongation is an event determined by template sequence.
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Self-citationA Novel Closed-Circular Mitochondrial DNA with Properties of a Replicating Intermediate
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Cited by
The mitochondrial genome: structure, transcription, translation and replication
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Metadata
- Authors
- Doda, J. N., Wright, C. T., & Clayton, D. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1981-10
- Volume
- 78
- Issue
- 10
- Pages
- 6116-6120
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2030230379
- Cited by
- 310
- References
- 11
- FWCI
- 1.18
- Type
- journal article
- Language
- en
- Open access
- green
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- Doda, J. N., Wright, C. T., & Clayton, D. A. (1981). Elongation of displacement-loop strands in human and mouse mitochondrial DNA is arrested near specific template sequences. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.78.10.6116
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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