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Inversions between ribosomal RNA genes of Escherichia coli.
Open accessAbstract
It might be anticipated that the presence of redundant but oppositely oriented sequences in a chromosome could allow inversion of the intervening material through homologous recombination. For example, the ribosomal RNA gene rrnD of Escherichia coli has the opposite orientation fro rrnB and rrnE and is separated from these genes by roughly 20% of the chromosome. Starting with a derivative of Cavalli Hfr, we have constructed mutants that have an inversion of the segment between rrnD and either rrnB or rrnE. These mutants are generally quite viable but do exhibit a slight reduction in growth rate relative to the parental strain. A major line of laboratory E. coli, W3110 and its derivatives, also has an inversion between rrnD and rrnE, probably created directly by a recombinational event between these highly homologous genes.
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Citations
Cited by
Linkage map of Escherichia coli K-12, edition 7
Bachmann, B. (1983) · Microbiological Reviews · doi:10.1128/mmbr.47.2.180-230.1983 · Cited by 1,438
Escherichia coli K-12: a cooperatively developed annotation snapshot--2005
Riley, M. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkj405 · Cited by 608
Organization of the bacterial chromosome
KRAWIEC, S., & Riley, M. (1990) · Microbiological Reviews · doi:10.1128/mmbr.54.4.502-539.1990 · Cited by 386
RECOMBINATION BETWEEN REPEATED GENES IN MICROORGANISMS
Petes, T. D., & Hill, C. W. (1988) · Annual Review of Genetics · doi:10.1146/annurev.ge.22.120188.001051 · Cited by 257
Self-citationEscherichia coli has two homologous glutamate decarboxylase genes that map to distinct loci
Smith, D. K., Kassam, T., Singh, B., & Elliott, J. F. (1992) · Journal of Bacteriology · doi:10.1128/jb.174.18.5820-5826.1992 · Cited by 208
Metadata
- Authors
- Hill, C. W., & Harnish, B. W.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1981-11
- Volume
- 78
- Issue
- 11
- Pages
- 7069-7072
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2061527369
- Cited by
- 245
- References
- 0
- FWCI
- 1.89
- Type
- journal article
- Language
- en
- Open access
- green
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