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Inhibition of fructose-1,6-bisphosphatase by fructose 2,6-biphosphate.
Open accessAbstract
Fructose 2,6-bisphosphate, a known powerful stimulator of phosphofructokinase [Van Schaftingen, E., Hue, L. & Hers, H.-G. (1980) Biochem. J. 192, 897-901] was found to inhibit, at micromolar concentrations, liver and muscle fructose-1,6-biphosphate (D-fructose-1,6-bisphosphate 1-phosphohydrolase, EC 3.1.3.11). The main characteristics of this inhibition are that (i) it is much stronger at low than at high substrate concentrations, (ii) it changes the substrate saturation curve from almost hyperbolic to sigmoidal, and (iii) it is synergistic with the inhibition by AMP. This inhibition may play an important role in the stimulation of gluconeogenesis by glucagon, because this hormone is known to decrease the concentration of fructose 2,6-bisphosphate in the liver [Van Schaftingen, E., Hue, L. & Hers, H.-G. (1980) Biochem. J. 192, 887-895].
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Cited by
The role of protein phosphorylation in neural and hormonal control of cellular activity
Cohen, P. (1982) · Nature · doi:10.1038/296613a0 · Cited by 1,123
Trehalose – The Insect ‘Blood’ Sugar
Thompson, S. N. (2003) · Advances in Insect Physiology · doi:10.1016/s0065-2806(03)31004-5 · Cited by 447
Fructose 2,6-bisphosphate 2 years after its discovery
Hers, H. G., & Van Schaftingen, E. (1982) · Biochemical Journal · doi:10.1042/bj2060001 · Cited by 431
Self-citationRole of fructose 2,6-bisphosphate in the control of glycolysis in mammalian tissues
Hue, L., & Rider, M. H. (1987) · Biochemical Journal · doi:10.1042/bj2450313 · Cited by 422
Mechanisms of blood glucose homeostasis
Hers, H. ‐. (1990) · Journal of Inherited Metabolic Disease · doi:10.1007/bf01799497 · Cited by 61
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Metadata
- Authors
- Van Schaftingen, E., & Hers, H. G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1981-05
- Volume
- 78
- Issue
- 5
- Pages
- 2861-2863
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2102311630
- Cited by
- 255
- References
- 0
- FWCI
- 9.98
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Van Schaftingen, E., & Hers, H. G. (1981). Inhibition of fructose-1,6-bisphosphatase by fructose 2,6-biphosphate. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.78.5.2861
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