The DOI matches its Crossref record.
Regulation of collagen synthesis by ascorbic acid.
Open accessAbstract
After prolonged exposure to ascorbate, collagen synthesis in cultured human skin fibroblasts increased approximately 8-fold with no significant change in synthesis of noncollagen protein. This effect of ascorbate appears to be unrelated to its cofactor function in collagen hydroxylation. The collagenous protein secreted in the absence of added ascorbate was normal in hydroxylysine but was mildly deficient in hydroxyproline. In parallel experiments, lysine hydroxylase (peptidyllysine, 2-oxoglutarate:oxygen 5-oxidoreductase, EC 1.14.11.4) activity increased 3-fold in response to ascorbate administration whereas proline hydroxylase (prolyl-glycyl-peptide, 2-oxoglutarate:oxygen oxidoreductase, EC 1.14.11.2) activity decreased considerably. These results suggest that collage polypeptide synthesis, posttranslational hydroxylations, and activities of the two hydroxylases are independently regulated by ascorbate.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Tanaka, H. (2000) · Archives of Surgery · doi:10.1001/archsurg.135.3.326 · Cited by 438
Role of Vitamin C in the Function of the Vascular Endothelium
May, J. M., & Harrison, F. E. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2013.5205 · Cited by 358
Nusgens, B. V., Colige, A. C., Lambert, C. A., Lapière, C. M., Humbert, P., Rougier, A., Haftek, M., Richard, A., & Creidi, P. (2001) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01362.x · Cited by 262
Humbert, P. G., Haftek, M., Creidi, P., Lapière, C., Nusgens, B., Richard, A., Schmitt, D., Rougier, A., & Zahouani, H. (2003) · Experimental Dermatology · doi:10.1034/j.1600-0625.2003.00008.x · Cited by 255
Geesin, J. C., Darr, D., Kaufman, R., Murad, S., & Pinnell, S. R. (1988) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12460849 · Cited by 203
Metadata
- Authors
- Murad, S., Grove, D., Lindberg, K. A., Reynolds, G., Sivarajah, A., & Pinnell, S. R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1981-05
- Volume
- 78
- Issue
- 5
- Pages
- 2879-2882
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2064481190
- Cited by
- 493
- References
- 0
- FWCI
- 7.77
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Regulation of collagen synthesis by ascorbic acid. https://app.cochat.ai/papers/10.1073/pnas.78.5.2879
- The paper
- Murad, S., Grove, D., Lindberg, K. A., Reynolds, G., Sivarajah, A., & Pinnell, S. R. (1981). Regulation of collagen synthesis by ascorbic acid. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.78.5.2879
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
