The DOI matches its Crossref record.
Chemically synthesized peptides predicted from the nucleotide sequence of the hepatitis B virus genome elicit antibodies reactive with the native envelope protein of Dane particles.
Open accessAbstract
Thirteen peptides corresponding to amino acid sequences predicted from the nucleotide sequence of the hepatitis B surface antigen were synthesized chemically. The free or carrier-linked synthetic peptides were injected into rabbits, and 7 of the 13 elicited an antipeptide response. Antisera against four of the six soluble peptides longer than 10 amino acids were reactive with native antigen and specifically precipitated the 23,000- and 28,000-dalton forms from Dane particles. As the hepatitis molecule had not been chosen for study because of any structural feature suggesting unique opportunities for success, these results suggest that the strategy is general and should work for any protein as long as enough domains are studied. Peptides such as these could prove to be ideal vaccines.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Tiollais, P., Pourcel, C., & Dejean, A. (1985) · Nature · doi:10.1038/317489a0 · Cited by 1,205
Osada, S., Mizuno, K., Saido, T. C., Akita, Y., Suzuki, K., Kuroki, T., & Ohno, S. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)45723-7 · Cited by 428
The primary structure and genetic organization of the bovine papillomavirus type 1 genome
Chen, E. Y., Howley, P. M., Levinson, A. D., & Seeburg, P. H. (1982) · Nature · doi:10.1038/299529a0 · Cited by 362
Antibodies against a preselected peptide recognize and neutralize foot and mouth disease virus.
Pfaff, E., Mussgay, M., Böhm, H. O., Schulz, G. E., & Schaller, H. (1982) · The EMBO Journal · doi:10.1002/j.1460-2075.1982.tb01262.x · Cited by 361
Sung, C., Makino, C., Baylor, D., & Nathans, J. (1994) · The Journal of Neuroscience · doi:10.1523/jneurosci.14-10-05818.1994 · Cited by 342
Metadata
- Authors
- Lerner, R. A., Green, N., Alexander, H., Liu, F. T., Sutcliffe, J. G., & Shinnick, T. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1981-06
- Volume
- 78
- Issue
- 6
- Pages
- 3403-3407
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2027211023
- Cited by
- 409
- References
- 0
- FWCI
- 44.04
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Chemically synthesized peptides predicted from the nucleotide sequence of the hepatitis B virus genome elicit antibodies reactive with the native envelope protein of Dane particles. https://app.cochat.ai/papers/10.1073/pnas.78.6.3403
- The paper
- Lerner, R. A., Green, N., Alexander, H., Liu, F. T., Sutcliffe, J. G., & Shinnick, T. M. (1981). Chemically synthesized peptides predicted from the nucleotide sequence of the hepatitis B virus genome elicit antibodies reactive with the native envelope protein of Dane particles. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.78.6.3403
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
