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Control of liver 6-phosphofructokinase by fructose 2,6-bisphosphate and other effectors.
Open accessAbstract
Rat liver 6-phosphofructokinase (ATP-D-fructose-6-phosphate 1-phosphotransferase, EC 2.7.1.11) was partially purified free of interfering enzymes by a rapid procedure. Fructose 2,6-bisphosphate, at micromolar concentrations, greatly stimulated the enzyme by increasing its affinity for fructose 6-phosphate and relieving the inhibition by ATP. Its action was synergistic with that of AMP. As a stimulator of liver phosphofructokinase, fructose 2,6-bisphosphate was approximately 1000- and 2500-fold more efficient than fructose 1,6-bisphosphate and glucose 1,6-bisphosphate, respectively. The concentration at which a half-maximal effect was obtained with the hexose bisphosphates was dependent upon the experimental conditions. It was relatively high at physiological concentrations of substrates, AMP, and Pi, and under these conditions the positive effect of fructose 1,6-bisphosphate was no longer detectable. This was probably due to the negative effect of fructose 1,6-bisphosphate as a reaction product inhibitor. It is concluded that fructose 2,6-bisphosphate rather than fructose 1,6-bisphosphate controls, in association with other effectors, the activity of phosphofructokinase in the liver.
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Citations
Cited by
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Vander Heiden, M. G., Plas, D. R., Rathmell, J. C., Fox, C. J., Harris, M. H., & Thompson, C. B. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.17.5899-5912.2001 · Cited by 536
Changes in Nutritional Status Impact Immune Cell Metabolism and Function
Alwarawrah, Y., Kiernan, K., & MacIver, N. J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01055 · Cited by 513
Clem, B., Telang, S., Clem, A., Yalcin, A., Meier, J., Simmons, A., Rasku, M. A., Arumugam, S., Dean, W. L., Eaton, J., et al. (2008) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-07-0482 · Cited by 432
Fructose 2,6-bisphosphate 2 years after its discovery
Hers, H. G., & Van Schaftingen, E. (1982) · Biochemical Journal · doi:10.1042/bj2060001 · Cited by 431
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Metadata
- Authors
- Van Schaftingen, E., Jett, M. F., Hue, L., & Hers, H. G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1981-06
- Volume
- 78
- Issue
- 6
- Pages
- 3483-3486
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2156521589
- Cited by
- 246
- References
- 0
- FWCI
- 7.78
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Van Schaftingen, E., Jett, M. F., Hue, L., & Hers, H. G. (1981). Control of liver 6-phosphofructokinase by fructose 2,6-bisphosphate and other effectors. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.78.6.3483
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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