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Complete amino acid sequence of beta-tubulin from porcine brain.
Open accessAbstract
The primary structure of porcine brain beta-tubulin was determined by automated and manual Edman degradation of six sets of overlapping peptides. The protein consists of 445 amino acid residues and has a minimum of six positions that are heterogeneous, indicating at least two beta-tubulins in porcine brain. Comparison of the optimally aligned sequences of alpha-tubulin and beta-tubulin indicates that 41% of their primary structures are identical. A region rich in glycyl residues is similar both in sequence and predicted secondary structure to the phosphate binding loop of several nucleotide binding enzymes. beta-Tubulin contains a highly acidic COOH-terminal region that resembles the NH2-terminus of troponin T.
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Cited by
Walker, J. E., Saraste, M., Runswick, M. J., & Gay, N. J. (1982) · The EMBO Journal · doi:10.1002/j.1460-2075.1982.tb01276.x · Cited by 5,312
Microtubule Organizing Centers
Brinkley, B. R. (1985) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.01.110185.001045 · Cited by 414
Isolation of the β-tubulin gene from yeast and demonstration of its essential function in vivo
Neff, N. F., Thomas, J. H., Grisafi, P., & Botstein, D. (1983) · Cell · doi:10.1016/0092-8674(83)90350-1 · Cited by 411
Sullivan, K. F., & Cleveland, D. W. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.12.4327 · Cited by 400
Contribution of the Surface Free Energy Perturbation to Protein-Solvent Interactions
Kita, Y., Arakawa, T., Lin, T.-Y., & Timasheff, S. N. (1994) · Biochemistry · doi:10.1021/bi00254a029 · Cited by 300
Metadata
- Authors
- Krauhs, E., Little, M., Kempf, T., Hofer-Warbinek, R., Ade, W., & Ponstingl, H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1981-07
- Volume
- 78
- Issue
- 7
- Pages
- 4156-4160
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1990343615
- Cited by
- 305
- References
- 0
- FWCI
- 11.37
- Type
- journal article
- Language
- en
- Open access
- green
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- Krauhs, E., Little, M., Kempf, T., Hofer-Warbinek, R., Ade, W., & Ponstingl, H. (1981). Complete amino acid sequence of beta-tubulin from porcine brain. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.78.7.4156
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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