The DOI matches its Crossref record.
Polymorphic DNA region adjacent to the 5' end of the human insulin gene.
Open accessAbstract
The length of a segment of DNA associated with the human insulin gene, which has been localized to the short arm of chromosome 11, is heterozygous in 63% of 52 individuals analyzed. This polymorphic region is approximately 500 base pairs from the nucleotide encoding the 5' end of insulin mRNA. The polymorphism appears to be due to an insertion or deletion of DNA sequences so that DNA fragments of different length are generated when DNA from a heterozygous individual is digested with selected restriction endonucleases.
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Cited by
Shimkets, R. A., Warnock, D. G., Bositis, C. M., Nelson-Williams, C., Hansson, J. H., Schambelan, M., Gill, J. R., Ulick, S., Milora, R. V., Findling, J. W., et al. (1994) · Cell · doi:10.1016/0092-8674(94)90250-x · Cited by 1,259
Lifton, R. P., Dluhy, R. G., Powers, M., Rich, G. M., Cook, S., Ulick, S., & Lalouel, J.-M. (1992) · Nature · doi:10.1038/355262a0 · Cited by 1,158
Chang, S. S., Grunder, S., Hanukoglu, A., Rösler, A., Mathew, P. M., Hanukoglu, I., Schild, L., Lu, Y., Shimkets, R. A., Nelson-Williams, C., et al. (1996) · Nature Genetics · doi:10.1038/ng0396-248 · Cited by 808
Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndrome
Bamshad, M., Lin, R. C., Law, D. J., Watkins, W. S., Krakowiak, P. A., Moore, M. E., Franceschini, P., Lala, R., Holmes, L. B., Gebuhr, T. C., et al. (1997) · Nature Genetics · doi:10.1038/ng0797-311 · Cited by 540
Parker, H. G., Dreger, D. L., Rimbault, M., Davis, B. W., Mullen, A. B., Carpintero-Ramirez, G., & Ostrander, E. A. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.03.079 · Cited by 435
Metadata
- Authors
- Bell, G. I., Karam, J. H., & Rutter, W. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1981-09
- Volume
- 78
- Issue
- 9
- Pages
- 5759-5763
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2058831382
- Cited by
- 889
- References
- 0
- FWCI
- 22.36
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Polymorphic DNA region adjacent to the 5' end of the human insulin gene. https://app.cochat.ai/papers/10.1073/pnas.78.9.5759
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- Bell, G. I., Karam, J. H., & Rutter, W. J. (1981). Polymorphic DNA region adjacent to the 5' end of the human insulin gene. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.78.9.5759
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