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Interferon-dependent induction of mRNA for the major histocompatibility antigens in human fibroblasts and lymphoblastoid cells.
Open accessAbstract
In human cells treated with interferons, there is an increase in the amount of HLA-A,B,C and beta 2-microglobulin exposed on the cell surface. We have used a cloned HLA-A,B,C cDNA probe to demonstrate by molecular hybridization that this effect of interferon is preceded by a large increase in the amount of HLA mRNA in the cell. This effect was found in five different human cell lines, with purified leukocyte and fibroblast interferons. The increase in HLA mRNA is comparable in its kinetics and dose-response to the induction of (2'-5') oligo(A) synthetase mRNA by interferons. Therefore, interferons seem to activate at least two cellular genes which have different biochemical functions.
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Citations
Cited by
Interferon-γ: an overview of signals, mechanisms and functions
Schroder, K., Hertzog, P. J., Ravasi, T., & Hume, D. A. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0603252 · Cited by 4,120
Collins, T., Korman, A. J., Wake, C. T., Boss, J. M., Kappes, D. J., Fiers, W., Ault, K. A., Gimbrone, M. A., Strominger, J. L., & Pober, J. S. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.15.4917 · Cited by 585
Identification of a set of genes expressed during the G0/G1 transition of cultured mouse cells.
Lau, L. F., & Nathans, D. (1985) · The EMBO Journal · doi:10.1002/j.1460-2075.1985.tb04057.x · Cited by 567
Genes regulating HLA class I antigen expression in T-B lymphoblast hybrids
Salter, R. D., Howell, D. N., & Cresswell, P. (1985) · Immunogenetics · doi:10.1007/bf00375376 · Cited by 566
The interferon system of teleost fish
Robertsen, B. (2006) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2005.01.010 · Cited by 561
Metadata
- Authors
- Fellous, M., Nir, U., Wallach, D., Merlin, G., Rubinstein, M., & Revel, M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1982-05
- Volume
- 79
- Issue
- 10
- Pages
- 3082-3086
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2134743660
- Cited by
- 261
- References
- 0
- FWCI
- 13.33
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Interferon-dependent induction of mRNA for the major histocompatibility antigens in human fibroblasts and lymphoblastoid cells. https://app.cochat.ai/papers/10.1073/pnas.79.10.3082
- The paper
- Fellous, M., Nir, U., Wallach, D., Merlin, G., Rubinstein, M., & Revel, M. (1982). Interferon-dependent induction of mRNA for the major histocompatibility antigens in human fibroblasts and lymphoblastoid cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.79.10.3082
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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