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Antigen presentation by Ia+ B cell hybridomas to H-2-restricted T cell hybridomas.
Open accessAbstract
The Ia+, H-2d BALB/c lymphoma cell line L10.A 2J was fused to T cell-depleted spleen cells from mouse strains bearing other H-2 haplotypes. A portion of the selected hybrids expressed Ia antigens of the normal spleen cell partner in the fusion as evidenced by their presentation of various antigens to a set of antigen-specific I-region-restricted T cell hybridomas. Three cloned hybrids were studied in detail. Antigen presentation was shown to be inhibited specifically by monoclonal anti-Ia antibodies. Both I-A and I-E molecules were expressed, including in the one case examined hybrid I-A and I-E molecules between the H-2d and H-2b haplotypes. These Ia+ B cell hybridomas provide a useful set of tools for studying the role of I-region-encoded molecules in antigen presentation to T cells.
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Cited by
Rock, K. L., Gramm, C., Rothstein, L., Clark, K., Stein, R., Dick, L., Hwang, D., & Goldberg, A. L. (1994) · Cell · doi:10.1016/s0092-8674(94)90462-6 · Cited by 2,524
ROLE OF ABERRANT HLA-DR EXPRESSION AND ANTIGEN PRESENTATION IN INDUCTION OF ENDOCRINE AUTOIMMUNITY
Bottazzo, G., Hanafusa, T., Pujol-Borrell, R., & Feldmann, M. (1983) · The Lancet · doi:10.1016/s0140-6736(83)90629-3 · Cited by 1,256
Identification of the components of the murine T cell antigen receptor complex
Samelson, L. (1985) · Cell · doi:10.1016/0092-8674(85)90027-3 · Cited by 337
Metadata
- Authors
- Kappler, J., White, J., Wegmann, D., Mustain, E., & Marrack, P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1982-06
- Volume
- 79
- Issue
- 11
- Pages
- 3604-3607
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1989402394
- Cited by
- 242
- References
- 0
- FWCI
- 5.79
- Type
- journal article
- Language
- en
- Open access
- green
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- Kappler, J., White, J., Wegmann, D., Mustain, E., & Marrack, P. (1982). Antigen presentation by Ia+ B cell hybridomas to H-2-restricted T cell hybridomas. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.79.11.3604
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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