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Cited by 242

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Antigen presentation by Ia+ B cell hybridomas to H-2-restricted T cell hybridomas.

Open access
Kappler, J, White, J, Wegmann, D, Mustain, E, Marrack, P·1982·Proceedings of the National Academy of Sciences

Abstract

The Ia+, H-2d BALB/c lymphoma cell line L10.A 2J was fused to T cell-depleted spleen cells from mouse strains bearing other H-2 haplotypes. A portion of the selected hybrids expressed Ia antigens of the normal spleen cell partner in the fusion as evidenced by their presentation of various antigens to a set of antigen-specific I-region-restricted T cell hybridomas. Three cloned hybrids were studied in detail. Antigen presentation was shown to be inhibited specifically by monoclonal anti-Ia antibodies. Both I-A and I-E molecules were expressed, including in the one case examined hybrid I-A and I-E molecules between the H-2d and H-2b haplotypes. These Ia+ B cell hybridomas provide a useful set of tools for studying the role of I-region-encoded molecules in antigen presentation to T cells.

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Metadata

Authors
Kappler, J., White, J., Wegmann, D., Mustain, E., & Marrack, P.
Venue
Proceedings of the National Academy of Sciences
Published
1982-06
Volume
79
Issue
11
Pages
3604-3607
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W1989402394
Cited by
242
References
0
FWCI
5.79
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Antigen presentation by Ia+ B cell hybridomas to H-2-restricted T cell hybridomas. https://app.cochat.ai/papers/10.1073/pnas.79.11.3604
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Kappler, J., White, J., Wegmann, D., Mustain, E., & Marrack, P. (1982). Antigen presentation by Ia+ B cell hybridomas to H-2-restricted T cell hybridomas. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.79.11.3604

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.