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Calcium/phospholipid regulates phosphorylation of a Mr "87k" substrate protein in brain synaptosomes.
Open accessAbstract
Depolarization-induced calcium influx into rat cerebral cortex synaptosomes increased the phosphorylation of several synaptosomal proteins as examined by 32Pi incorporation. A phosphopeptide mapping technique involving NaDodSO4/polyacrylamide gels has been used to show that phosphorylation of a Mr 87,000 substrate protein is stimulated by depolarization-induced calcium influx. Phosphorylation of this Mr 87,000 substrate occurred in synaptosomal cytosol and was markedly stimulated by calcium/phosphatidylserine. Calmodulin inhibited this phosphorylation reaction. This substrate for calcium/phospholipid-dependent protein kinase is enriched in and appears to be specific to neurons.
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Citations
Cited by
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Nishizuka, Y. (1984) · Science · doi:10.1126/science.6147898 · Cited by 1,614
Hartwig, J. H., Thelen, M., Resen, A., Janmey, P. A., Nairn, A. C., & Aderem, A. (1992) · Nature · doi:10.1038/356618a0 · Cited by 730
Self-citationOuimet, C., Miller, P., Hemmings, H., Walaas, S., & Greengard, P. (1984) · The Journal of Neuroscience · doi:10.1523/jneurosci.04-01-00111.1984 · Cited by 656
Self-citationProtein Phosphorylation and Neuronal Function
Browning, M. D., Huganir, R., & Greengard, P. (1985) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1985.tb05468.x · Cited by 526
Self-citationProtein kinase C and the regulation of the actin cytoskeleton
Larsson, C. (2006) · Cellular Signalling · doi:10.1016/j.cellsig.2005.07.010 · Cited by 388
Metadata
- Authors
- Wu, W. C., Walaas, S. I., Nairn, A. C., & Greengard, P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1982-09
- Volume
- 79
- Issue
- 17
- Pages
- 5249-5253
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2042251760
- Cited by
- 256
- References
- 0
- FWCI
- 4.58
- Type
- journal article
- Language
- en
- Open access
- green
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- Wu, W. C., Walaas, S. I., Nairn, A. C., & Greengard, P. (1982). Calcium/phospholipid regulates phosphorylation of a Mr "87k" substrate protein in brain synaptosomes. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.79.17.5249
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
