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n-Tetradecanoyl is the NH2-terminal blocking group of the catalytic subunit of cyclic AMP-dependent protein kinase from bovine cardiac muscle.
Open accessAbstract
The unusual NH2-terminal blocking group of the catalytic subunit of bovine cardiac muscle cyclic AMP-dependent protein was found to be amide-linked n-tetradecanoic acid by gas chromatographic-, direct chemical ionization-, and fast atom bombardment-mass spectrometry. In addition, fast atom bombardment mass spectrometry revealed the presence of an additional alanine which had been overlooked when the original sequence was determined. The corrected and completed NH2-terminal sequence of the 350-amino acid catalytic subunit is CH3(CH2)12CONH-Gly-Asn-Ala-Ala-Ala-Ala-Lys.
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Citations
Cited by
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Evolutionary and cellular analysis of the ‘dark’ pseudokinase PSKH2
Byrne, D. P., Shrestha, S., Daly, L. A., Marensi, V., Ramakrishnan, K., Eyers, C. E., Kannan, N., & Eyers, P. A. (2023) · Biochemical Journal · doi:10.1042/bcj20220474 · Cited by 5
Metadata
- Authors
- Carr, S. A., Biemann, K., Shoji, S., Parmelee, D. C., & Titani, K.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1982-10
- Volume
- 79
- Issue
- 20
- Pages
- 6128-6131
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2010002190
- Cited by
- 388
- References
- 0
- FWCI
- 9.66
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: n-Tetradecanoyl is the NH2-terminal blocking group of the catalytic subunit of cyclic AMP-dependent protein kinase from bovine cardiac muscle. https://app.cochat.ai/papers/10.1073/pnas.79.20.6128
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- Carr, S. A., Biemann, K., Shoji, S., Parmelee, D. C., & Titani, K. (1982). n-Tetradecanoyl is the NH2-terminal blocking group of the catalytic subunit of cyclic AMP-dependent protein kinase from bovine cardiac muscle. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.79.20.6128
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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