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Cited by 380

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T-cell cloning to detect the mutant 6-thioguanine-resistant lymphocytes present in human peripheral blood.

Open access
Albertini, R J, Castle, K L, Borcherding, W R·1982·Proceedings of the National Academy of Sciences

Abstract

Rare thioguanine-resistant T lymphocytes, present in vivo in human peripheral blood, were isolated and grown in vitro as thioguanine-resistant cultured T cells. The conditions for their selection in vitro were such that thioguanine resistance had to have arisen in vivo. The mutant cells bore T-cell surface markers, maintained their thioguanine resistance in vitro in the presence or absence of selection, and were deficient in hypoxanthine-guanine phosphoribosyltransferase activity.

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Metadata

Authors
Albertini, R. J., Castle, K. L., & Borcherding, W. R.
Venue
Proceedings of the National Academy of Sciences
Published
1982-11
Volume
79
Issue
21
Pages
6617-6621
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2046775765
Cited by
380
References
0
FWCI
6.06
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: T-cell cloning to detect the mutant 6-thioguanine-resistant lymphocytes present in human peripheral blood. https://app.cochat.ai/papers/10.1073/pnas.79.21.6617
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Albertini, R. J., Castle, K. L., & Borcherding, W. R. (1982). T-cell cloning to detect the mutant 6-thioguanine-resistant lymphocytes present in human peripheral blood. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.79.21.6617

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.