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Isolation and preliminary characterization of the GAL4 gene, a positive regulator of transcription in yeast.
Open accessAbstract
The GAL4 locus encodes a positive regulator of the inducible galactose and melibiose genes of yeast. Using the yeast plasmid vector YEp13, we have cloned GAL4 by complementation of a gal4 mutation. Restriction endonuclease mapping of subclone DNA has delimited the region sufficient for complementation to a 3.2-kilobase segment of DNA. The GAL4 mRNA is 2.8 kilobases long, sufficient to encode a protein as large as 105,000 daltons. The concentration of the GAL4 transcript is about 0.1 per cell and is almost identical in galactose-induced and noninduced cells. This result is consistent with a previously proposed model in which the activity of the GAL4 protein and not the transcription of the GAL4 gene is modulated by galactose induction.
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Citations
Cited by
Elevated recombination rates in transcriptionally active DNA
Thomas, B. J., & Rothstein, R. (1989) · Cell · doi:10.1016/0092-8674(89)90584-9 · Cited by 1,616
Sequences that regulate the divergent GAL1-GAL10 promoter in Saccharomyces cerevisiae.
Johnston, M., & Davis, R. W. (1984) · Molecular and Cellular Biology · doi:10.1128/mcb.4.8.1440 · Cited by 1,012
A model fungal gene regulatory mechanism: the GAL genes of Saccharomyces cerevisiae
Johnston, M. (1987) · Microbiological Reviews · doi:10.1128/mmbr.51.4.458-476.1987 · Cited by 745
A Fungal Family of Transcriptional Regulators: the Zinc Cluster Proteins
MacPherson, S., Larochelle, M., & Turcotte, B. (2006) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00015-06 · Cited by 612
West, R. W., Yocum, R. R., & Ptashne, M. (1984) · Molecular and Cellular Biology · doi:10.1128/mcb.4.11.2467 · Cited by 416
Metadata
- Authors
- Laughon, A., & Gesteland, R. F.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1982-11
- Volume
- 79
- Issue
- 22
- Pages
- 6827-6831
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2093315295
- Cited by
- 168
- References
- 0
- FWCI
- 6.38
- Type
- journal article
- Language
- en
- Open access
- green
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- Laughon, A., & Gesteland, R. F. (1982). Isolation and preliminary characterization of the GAL4 gene, a positive regulator of transcription in yeast. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.79.22.6827
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