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Isolation and characterization of peptide YY (PYY), a candidate gut hormone that inhibits pancreatic exocrine secretion.
Open accessAbstract
A new candidate hormone--designated peptide YY (PYY)--has been isolated from extracts of porcine upper intestinal tissue by using a novel chemical assay method. This peptide has been detected in the extracts by the presence of its unusual COOH-terminal tyrosine amide structure. The peptide consists of a linear chain of 36 amino acids and its complete amino acid sequence is: Tyr-Pro-Ala-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Ser-Arg-Tyr -Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Val-Thr-Arg-Gln-Arg-Tyr-NH2. This peptide has a distinct sequence homology to the pancreatic polypeptide. It is therefore proposed that PYY and the pancreatic polypeptide together form a new peptide family. PYY has been found to strongly inhibit both secretin- and cholecystokinin-stimulated pancreatic secretion in the anesthetized cat.
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Cited by
Prolactin: structure, function, and regulation of secretion
Freeman, M. E., Kanyicska, B., Lerant, A., & Nagy, G. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.4.1523 · Cited by 2,457
Neuropeptide Y: complete amino acid sequence of the brain peptide.
Tatemoto, K. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.18.5485 · Cited by 1,378
Self-citationLambeir, A.-M., Durinx, C., Scharpé, S., & De Meester, I. (2003) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/713609354 · Cited by 955
Pancreatic Polypeptide: A Hormone Under Vagal Control
Schwartz, T. W. (1983) · Gastroenterology · doi:10.1016/s0016-5085(83)80027-4 · Cited by 426
Haynes, A. C., Jackson, B., Overend, P., Buckingham, R. E., Wilson, S., Tadayyon, M., & Arch, J. R. S. (1999) · Peptides · doi:10.1016/s0196-9781(99)00105-9 · Cited by 306
Metadata
- Authors
- Tatemoto, K.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1982-04
- Volume
- 79
- Issue
- 8
- Pages
- 2514-2518
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2079042881
- Cited by
- 612
- References
- 0
- FWCI
- 11.19
- Type
- journal article
- Language
- en
- Open access
- green
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- Tatemoto, K. (1982). Isolation and characterization of peptide YY (PYY), a candidate gut hormone that inhibits pancreatic exocrine secretion. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.79.8.2514
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