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Subfragments of the large terminal repeat cause glucocorticoid-responsive expression of mouse mammary tumor virus and of an adjacent gene.
Open accessAbstract
After transfection of mouse mammary tumor virus (MMTV) proviral DNA into cultured cells, the DNA is transcribed in a glucocorticoid-sensitive fashion. The large terminal repeat (LTR) region of MMTV is 1,328 nucleotides long and contains the regulatory information necessary for the hormonal response. We have constructed a MMTV LTR-thymidine kinase (tk) chimeric gene and have tested the biological activity of molecules containing various deletions in the LTR after transformation of LTK- APRT- mouse cells. In the TK+ transformants, both a LTR- tk chimeric RNA and an authentic tk RNA are correctly initiated and transcribed. The synthesis of the chimeric RNA as well as that of the tk RNA is hormonally regulated. A plasmid containing 202 nucleotides of LTR DNA 5' to the RNA initiation site is fully sensitive to glucocorticoids; 50 nucleotides still cause a residual inducibility.
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Cited by
Karin, M., Haslinger, A., Holtgreve, H., Richards, R. I., Krauter, P., Westphal, H. M., & Beato, M. (1984) · Nature · doi:10.1038/308513a0 · Cited by 907
Klein-Hitpaß, L., Schorpp, M., Wagner, U., & Ryffel, G. U. (1986) · Cell · doi:10.1016/0092-8674(86)90705-1 · Cited by 720
Functional interactions between Stat5 and the glucocorticoid receptor
Stöcklin, E., Wissler, M., Gouilleux, F., & Groner, B. (1996) · Nature · doi:10.1038/383726a0 · Cited by 675
Self-citationNegative Regulation by Glucocorticoids Through Interference with a cAMP Responsive Enhancer
Akerblom, I. E., Slater, E. P., Beato, M., Baxter, J. D., & Mellon, P. L. (1988) · Science · doi:10.1126/science.2838908 · Cited by 481
Piña, B., Brüggemeier, U., & Beato, M. (1990) · Cell · doi:10.1016/0092-8674(90)90087-u · Cited by 425
Metadata
- Authors
- Hynes, N., van Ooyen, A. J., Kennedy, N., Herrlich, P., Ponta, H., & Groner, B.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1983-06
- Volume
- 80
- Issue
- 12
- Pages
- 3637-3641
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1982765963
- Cited by
- 226
- References
- 0
- FWCI
- 25.24
- Type
- journal article
- Language
- en
- Open access
- green
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- Hynes, N., van Ooyen, A. J., Kennedy, N., Herrlich, P., Ponta, H., & Groner, B. (1983). Subfragments of the large terminal repeat cause glucocorticoid-responsive expression of mouse mammary tumor virus and of an adjacent gene. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.80.12.3637
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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