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Endogenous endonuclease-induced DNA fragmentation: an early event in cell-mediated cytolysis.
Open accessAbstract
Within minutes of exposure of target cells to cytotoxic T lymphocytes, their nuclear DNA begins to be fragmented. This phenomenon precedes 51Cr release by at least an hour. DNA fragmentation occurs only when appropriately sensitized cytotoxic T cells are used and is not merely a result of cell death because killing of target cells by heating, freeze/thawing, or lysing with antibody and complement did not yield DNA fragments. Agarose gel electrophoresis of target cell DNA showed discrete multiples of an approximately 200-base-pair subunit, suggesting that fragmentation was the result of activation of a specific endonuclease. A similar pattern of DNA fragments is observed during glucocorticoid-induced killing of mouse thymocytes. The endonuclease in that case is inhibited by zinc ions, and we find that Zn2+ also inhibits DNA fragmentation and 51Cr release induced by cytotoxic T cells, suggesting a final common biochemical pathway for both types of cell death.
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Cited by
Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.
Gavrieli, Y., Sherman, Y., & Ben-Sasson, S. A. (1992) · The Journal of cell biology · doi:10.1083/jcb.119.3.493 · Cited by 9,444
Zamzami, N., Marchetti, P., Castedo, M., Zanin, C., Vayssière, J. L., Petit, P. X., & Kroemer, G. (1995) · The Journal of experimental medicine · doi:10.1084/jem.181.5.1661 · Cited by 1,166
Schulze-Osthoff, K., Bakker, A. C., Vanhaesebroeck, B., Beyaert, R., Jacob, W. A., & Fiers, W. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42768-8 · Cited by 939
Chapter 9 The End of the (Cell) Line: Methods for the Study of Apoptosis in Vitro
McGahon, A. J., Martin, S. J., Bissonnette, R. P., Mahboubi, A., Shi, Y., Mogil, R. J., Nishioka, W. K., & Green, D. R. (1995) · Methods in Cell Biology · doi:10.1016/s0091-679x(08)61929-9 · Cited by 573
Programmed Cell Death in the Immune System
Cohen, J. J. (1991) · Advances in Immunology · doi:10.1016/s0065-2776(08)60822-6 · Cited by 560
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Metadata
- Authors
- Duke, R. C., Chervenak, R., & Cohen, J. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1983-10
- Volume
- 80
- Issue
- 20
- Pages
- 6361-6365
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1991605327
- Cited by
- 606
- References
- 0
- FWCI
- 2.91
- Type
- journal article
- Language
- en
- Open access
- green
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- Duke, R. C., Chervenak, R., & Cohen, J. J. (1983). Endogenous endonuclease-induced DNA fragmentation: an early event in cell-mediated cytolysis. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.80.20.6361
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